While perception is recognized as being atypical in individuals with autism spectrum conditions (ASC), the underlying mechanisms for such atypicality are unclear. Here we test the hypothesis that individuals with ASC will show enhanced orientation discrimination compared with neurotypical observers. This prediction is based both on anecdotal report of superior discriminatory skills in ASC and a...

We previously showed that in a two-alternative choice (2AC) task, olfactory bulb (OB) gamma oscillations (approximately 70 Hz in rats) were enhanced during discrimination of structurally similar odorants (fine discrimination) versus discrimination of dissimilar odorants (coarse discrimination). In other studies (mostly employing go/no-go tasks) in multiple labs, beta oscillations (15-35 Hz) dom...

26 27 We previously showed that in a 2-alternative choice (2AC) task, olfactory bulb (OB) 28 gamma oscillations (~70 Hz in rats) were enhanced during discrimination of structurally 29 similar odorants (fine discrimination) vs. discrimination of dissimilar odorants (coarse 30 discrimination). In other studies (mostly employing go/no-go tasks) in multiple labs, beta 31 oscillations (15-35 Hz) dom...

The R964C mutation of human DNA polymerase gamma was recently linked to stavudine (d4T)-mediated mitochondrial toxicity. We utilized pre-steady-state kinetics to determine the effect of this mutation on incorporation of natural substrate dTTP and the active metabolite of d4T (d4TTP). The R964C polymerase gamma holoenzyme demonstrated a 33% decrease in dTTP incorporation efficiency and a threefo...

In this paper, the generalized gamma (GG) distribution that is a flexible distribution in statistical literature, and has exponential, gamma, and Weibull as subfamilies, and lognormal as a limiting distribution is introduced. The power and logarithmic moments of this family is defined. A new moment estimation method of parameters of GG family using it’s characterization is presented, this metho...

Spatial visual attention enhances information processing within its focus. Vision at an attended location is faster, more accurate, of higher spatial resolution, and has an enhanced sensitivity for fine changes. Earlier hypotheses suggest that the neuronal mechanisms of these processes are based on the interactions among different neuronal groups by means of cortical oscillations in the gamma r...

Current models of attention, typically claim that vision and audition are limited by a common attentional resource which means that visual performance should be adversely affected by a concurrent auditory task and vice versa. Here, we test this implication by measuring auditory (pitch) and visual (contrast) thresholds in conjunction with cross-modal secondary tasks and find that no such interfe...

Cortical activity such as recorded by EEG or MEG is characterized by ongoing rhythms that encompass a wide range of temporal and spatial scales. Recent studies have suggested an oscillatory hierarchy with faster oscillations being locked to preferred phases of underlying slower waves, a functional principle applied up to the level of action potential generation. We here tested the idea that amp...