BACKGROUND Because ischemically injured myocardium is frequently composed of viable and nonviable portions, a method to discriminate the two is useful for clinical management. METHODS AND RESULTS Ischemically injured myocardium was characterized with extracellular nonspecific (Gd-DTPA) and necrosis-specific (mesoporphyrin) MR contrast media in rats. Relaxation rates (R1) were measured on day ...

Methods Patients (n = 84, age: 57.7 ± 14.7 yrs, [mean ± SD], LVEF: 25.7 ± 11.1%) with newly diagnosed NIDCM underwent late gadolinium enhancement CMR (inversion-recovery technique 10 min after the administration of gadolinium-DTPA (0.1 mmol/kg). Peak systolic circumferential (Εcc) and radial (Εrr) strain were assessed using FT-CMR of the mid-cavity LV short-axis cine and peak systolic longitudi...

Gadolinium (Gd)-DTPA-dimeglumine (tradename: Magnevist?) is the first commercially available contrast agent for magnetic resonance tomography (MRT). As a result of the very favourable results from preclinical and clinical investigations Magnevist? was granted a product license for cranial and spinal MRT in the Federal Republic of Germany in early February this year. Magnevist? is a paramagnetic...

A patient presented with sudden hearing loss on her first visit to our department. Gadolinium-DTPA-enhanced magnetic resonance imaging (MRI) of the posterior cranial fossa portrayed an intracanalicular tumour image (2-3 mm), and the pure tone average (PTA) and speech discrimination score (SDS) values were 65 dB and 60 per cent, respectively. Surgical intervention to remove the suspected tumour ...

This study describes a novel T1-weighted MR molecular imaging approach for sparse epitopes, such as the avb3integrin receptor in atherosclerotic angiogenesis, utilizing a soft Mn-based nanoparticle with high-relaxivity augmented by minute amounts of surface gadolinium. This new agent utilizes about 1/30th the amount of lanthanide used for PFC paramagnetic particles and reduces gadolinium exposu...

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volume-interpolate...

Strategies to enhance the relaxometric properties of gadolinium (Gd)-based contrast agents (CAs) for magnetic resonance imaging (MRI), without the chemical modification of chelates, have recently had a strong impact on the diagnostic field. We have taken advantage of the interaction between Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) and the hydrogel structure of hyaluronic acid t...

Primary hepatic angiosarcoma is the most common malignant mesenchymal tumor of the liver. It has a poor prognosis and various appearances on magnetic resonance (MR) images. We report a case of hepatic angiosarcoma with a characteristic appearance on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging in the hepatobiliary phase. A 72-year-old man was adm...

Biocompatible dual-modality imaging nanoprobes were synthesized by the electrostatic assembly of poly(γ-glutamic acid)[Gd-DTPA] and chitosan[IRDye800] and applied for the imaging of immune cells (phagocytic) and cancer cells (non-phagocytic).