نتایج جستجو برای: g6pd enzyme deficiency

تعداد نتایج: 369475  

2017
Maria Kahn Nicole LaRue Changcheng Zhu Sampa Pal Jack S Mo Lynn K Barrett Steve N Hewitt Mitchell Dumais Sandra Hemmington Adrian Walker Jeff Joynson Brandon T Leader Wesley C Van Voorhis Gonzalo J Domingo

BACKGROUND A large gap for the support of point-of-care testing is the availability of reagents to support quality control (QC) of diagnostic assays along the supply chain from the manufacturer to the end user. While reagents and systems exist to support QC of laboratory screening tests for glucose-6-phosphate dehydrogenase (G6PD) deficiency, they are not configured appropriately to support poi...

2011
Saorin Kim Chea Nguon Bertrand Guillard Socheat Duong Sophy Chy Sarorn Sum Sina Nhem Christiane Bouchier Magali Tichit Eva Christophel Walter R. J. Taylor John Kevin Baird Didier Menard

Development of reliable, easy-to-use, rapid diagnostic tests (RDTs) to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency at point of care is essential to deploying primaquine therapies as part of malaria elimination strategies. We assessed a kit under research and development called CareStart™ G6PD deficiency screening test (Access Bio, New Jersey, USA) by comparing its performance to ...

2017
Zeshuai Deng Fang Yang Yao Bai Lijun He Qing Li Yanrui Wu Lan Luo Hong Li Limei Ma Zhaoqing Yang Yongshu He Liwang Cui

Glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobin E (HbE, β26 Glu-Lys) are two common red cell disorders in Southeast Asia. G6PD deficiency produces hemolytic anemia, which can be triggered by certain drugs or infections. HbE is asymptomatic or is manifested as microcytic, minimally hemolytic anemia. The association between G6PD deficiency and HbE is little understood. This stu...

2013
Padmasree Dantu Srinivas Pusuluri

Glucose-6-phosphate dehydrogenase deficiency is a common hemolytic genetic disorder, particularly in the areas endemic to malaria. The risk of drug induced Glucose-6-phosphate dehydrogenase deficiency related hemolysis depends on a number of factors including the Glucose-6-phosphate dehydrogenase variant. Aims: To know the G6PD deficiency and identify its variants in drug induced hemolysis in m...

Journal: :International journal of laboratory hematology 2011
V Nadarajan H Shanmugam P Sthaneshwar S Jayaranee K S Sultan C Ang S Arumugam

INTRODUCTION The glucose-6-phosphate dehydrogenase (G6PD) fluorescent spot test (FST) is a useful screening test for G6PD deficiency, but is unable to detect heterozygote G6PD-deficient females. We sought to identify whether reporting intermediate fluorescence in addition to absent and bright fluorescence on FST would improve identification of mildly deficient female heterozygotes. METHODS A ...

Journal: :Journal of clinical pathology 1968
H C Lai M P Lai K S Leung

In a Chinese population 1,000 full-term male neonates and a further 117 jaundiced neonates of both sexes were studied in an investigation of the frequency of deficiency of erythrocyte glucose-6-phosphate dehydrogenase (G6PD). This enzyme was found to be deficient in 3.6% of male neonates. Correlation of the results with the birthplace of the 602 mothers who were known to come from Kwangtung pro...

2014
Youn-Kyoung Goo So-Young Ji Hyun-Il Shin Jun-Hye Moon Shin-Hyung Cho Won-Ja Lee Jung-Yeon Kim

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and affects more than 400 million people worldwide. This deficiency is believed to protect against malaria because its global distribution is similar. However, this genetic disorder may be associated with potential hemolytic anemia after treatment with anti-malarials, primaquine or other 8-amin...

ژورنال: Medical Laboratory Journal 2011
Abasi, Y, , Emadi, A, , Ghods, F, , Habibeh Najar, H, , Khaleghian, A, , Mohammadi, A., , Monem, M, , Nazari, H, , Salehiyan, A, ,

Abstract Background and objectives: Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway. G6PD deficiency (an X-linked recessive hereditary disease) is an inherited condition affecting approximately 3% of the people globally. This deficiency can cause hemolytic anemia and jaundice in neonates. The goal of this study is to detect the prevalence of G6PD deficienc...

2014
Mohammad EBRAHIMIPOUR Mehdi NATEGHPOUR Homa HAJJARAN Gholamhosein EDRISSIAN Mahmood JALALI Ahmad RAEISI Afsaneh MOTEVALLI HAGHI Leila FARIVAR Masomeh KHODADADI Abas RAHIMI-FROUSHANI

BACKGROUND One of the most important enzymatic disorders that interact with malaria is deficiency of G6PD (Gloucose-6-phosphate dehydrogenase). This enzyme protects red blood cells from hydrogen peroxide and other oxidative damages. Distribution of this enzyme deficiency usually accompanies with low level distribution of malaria disease in most malarious areas. So this hypothesis may be conside...

Journal: :Blood 1971
M C Rattazzi L M Corash G E van Zanen E R Jaffé S Piomelli

G6PD deficiency of the common type (Gd’ and Gd11t.d1 rranenn) results in extremely mild chronic hemolysis. In contrast, 65 males (from 47 unrelated families) have been reported with a different syndrome of severe chronic hemolysis associated with a superficially similar deficiency in the activity of G6PD. Five new such patients (from four unrelated families) are reported. Biochemical characteri...

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