Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1(-/-)mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either. Cell-based studies show that NPC1L1 is a much weaker transporter for phytosterols than cholesterol. In this study, we examined the role of NPC1L1 in phytosterol and cho...

objective: generation 5 poly (amidoamine) dendrimers are promising multipotent gene delivery vectors that provide favorable dna condensation properties; however, their high toxicity limits their applications. toxicity of pamam dendrimers depends on their type, generation and applied dosage in a way that lower generations (lower than g5 dendrimers) and anionic dendrimers have lower toxicity than...

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Tryptase, a protease produced by all mast cells, was evaluated as a clinical marker of systemic mastocytosis. Two sandwich immunoassays were evaluated, one which used the mAb G5 for capture, the other which used B12 for capture. The B12 capture assay measured both recombinant alpha- and beta-tryptase, whereas the G5 capture assay measured primarily recombinant beta-tryptase. G5 binds with low a...

Three soils of different content gypsum and lime were selected, the first soil (G1) second (G3), obtained near fields Faculty Agriculture, Tikrit University. As for third (G5), was taken from AL- alam Village side east city to a depth (0-10)cm. proportions 5%, 15%, 25%, 20%, 10% G1, G3, G5, respectively. Ferrous sulfate added as source iron ions three in following (0,10,25,50,100,150,250,500,75...

BACKGROUND Diabetes and cardiovascular disease have emerged as key threats to human health, and the risk is increased in individuals with visceral obesity. The consensus is that physical exercise should be part of the treatment of diabetes mellitus (DM). OBJECTIVE To compare the influence of guided and structured physical exercise programs (SPEP), three to five times per week, during a period...

The basic-helix-loop-helix-leucine-zipper domains of the c-Myc oncoprotein and its obligate partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. We have identified the binding sites and determined the structural means by which two unrelated small molecules, 10058-F4 and 10074-G5, bind c-Myc and stabilize the ID monomer over the...

A high-speed interface has been designed for interconnection of the S/390 I/O subsystem to the IBM S/390 G5 processor. The self-timed interface (STI) provides high bandwidth, greater communication distances, and simpler timing within the S/390 servers than traditional interfaces. The STI communicates between the memory bus adapter and the expanded S/390 I/O subsystem, which now includes the new...