نتایج جستجو برای: g4 5o2 95n2
تعداد نتایج: 3752 فیلتر نتایج به سال:
سابقه و هدف: علت اصلی پاتولوژیک بسیاری از بارداری های منجر به سقط همچنان ناشناخته مانده است. hla-g4 (human leukocyte antigen) و hla-g5 دو ایزوفرم غشایی (g4) و محلول (g5) از مولکول های غیر کلاسیک کلاس ib می باشند که در ایجاد تحمل بین مادر و جنین نقش دارند. در این مطالعه بیان این دو ایزوفرم و نیز بررسی تفاوت میزان تأثیر بیان هر آنتی ژن در زنان باردار تهدید به سقط در مقایسه با گروه شاهد ارزیابی شد...
استیل کولین استراز (ache) یک جز اصلی پیوندگاه عصبی عضلانی مهره داران است که انتقال عصبی کولینرژیک را با هیدرولیز استیل کولین رها شده از پایانه عصبی پایان می بخشد. استیل کولین استراز g4 به طور نزدیکی به ویژگی های پویایی عضله بستگی دارد. تغییرات سازشی ویژه ای در این نوع خاص از ایزوفرم استیل کولین استراز یعنی فرم تترامری g4 در عضلات تند تنش اندام عقبی موش صحرایی پس از دویدن روی تردمیل دیده شده است...
BACKGROUND Immunoglobulin G4-related disease is characterized by infiltration of immunoglobulin G4-positive plasmacytes in various organs. The radiological findings of lung involvement of immunoglobulin G4-related disease include hilar and mediastinal lymphadenopathies, thickness of bronchovascular bundles, peribronchovascular consolidation, and lung nodules. Although a pathological approach is...
A series of novel 2,4,6-triarylpyridines have been synthesized and their interactions with intramolecular G-quadruplexes have been measured by Förster Resonance Energy Transfer (FRET) melting and Fluorescent Intercalator Displacement (FID) assays. A few of these compounds exhibit stabilization of G4-DNA that is comparable to other benchmark G4-DNA ligands with fair to excellent G4-DNA vs. duple...
G-quadruplexes (G4) are extremely stable secondary structures forming stacks of guanine tetrads. DNA G4 structures have been extensively studied, however, less is known about G4 motifs in mRNAs, especially in their coding sequences. Herein, we show that Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) proto-oncogene in an arginine methylation-dependent manner. The Aven R...
Background and purpose: Major pathologic cause of abortions is unknown. HLA-G4 and HLA-G5 are two isoforms, membrane (G4) and soluble (G5) of nonclassical molecules of HLA-1b that can induce tolerance between mother and fetus. In this study, expression of two HLA-G isoforms and their effect were evaluated in threatened-abortion women in comparison with controls. Materials and methods: In a cas...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strands and play an important role in the maintenance of genomic integrity. Here we used single-molecul...
The promoter region of the imprinted gene MEST contains several motifs capable of forming G-quadruplex (G4) structures, which appear to contribute to consistent allelic dropout during polymerase chain reaction (PCR) analysis of this region. Here, we extend our previous analysis of MEST G4 structures by applying fluorescent footprinting techniques to assess non B-DNA structure and topology in ds...
G-quadruplexes (G4) are intricate RNA structures found throughout the transcriptome. Because they are associated with a variety of biological cellular mechanisms, these fascinating structural motifs are seen as potential therapeutic targets against many diseases. While screening of chemical compounds specific to G4 motifs has yielded interesting results, no single compound successfully discrimi...
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