In the search for responsive complexes with potential applications in formulation of smart dispersed systems such as foams, we hypothesized that a pH-responsive system could be formulated polyacrylic acid (PAA) mixed cationic surfactant, Gemini 12-2-12 (G12). We studied PAA-G12 at liquid–air interfaces by equilibrium and dynamic surface tension, rheology, X-ray reflectometry (XRR). found adsorb...

Crocidolite asbestos is known to cause cellular damage, leading to asbestosis, bronchogenic carcinoma, and mesothelioma in humans. The mechanism responsible for the carcinogenicity of asbestos is not known. Iron associated with asbestos is thought to play a role by catalyzing the formation of reactive oxygen species, which may cause DNA damage, leading to mutations and cancer. Here, we examined...

Department of Cell and Developmental Biology, John Innes Centre, Colney, Norwich, NR4 7UH, UK Environmental, Agricultural and Analytical Chemistry Section, Department of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK Integrated Microscopy Facility, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK Department of Bio...

Crocidante asbestos is known to cause cellular damage, leading to asbestosis, bronchogenic carcinoma, and mesothelioma in humans. The mechanism responsible for the carcinogenicity of asbestos is not known. Iron associated with asbestos is thought to play a role by catalyzing the formation of reactive oxygen species, which may cause DNA damage, leading to mutations and cancer. Here, we examined ...

We describe here the G12 pro-B cell clone that has been isolated from an IL-7 transgenic mouse. This clone has the phenotype B220+, BP-1+, HSA+, CD43+, lambda5+, and CD25-, and has its Ig locus in a germline configuration. G12 cells spontaneously express cell-surface MHC class II molecules, although to a much lesser extent than the mature M12.4.1 B-cell lymphoma. G12 cells can process and prese...

The G12 project recently started by National ICT Australia (NICTA) is an ambitious project to develop a software platform for solving large scale industrial combinatorial optimisation problems. The core design involves three languages: Zinc, Cadmium and Mercury (Group 12 of the periodic table). Zinc is a declarative modelling language for expressing problems, independent of any solving methodol...

The G12 subfamily of heterotrimeric G proteins, comprised of the a-subunits Ga12 and Ga13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis. In an attempt to elucidate specific roles of this subfamily in cell regulation, we sought to identify molecular targets of Ga12. Here we show a specific interaction between ...