نتایج جستجو برای: fxr

تعداد نتایج: 1033  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2013
Guodong Li Yan Zhu Ossama Tawfik Bo Kong Jessica A Williams Le Zhan Karen M Kassel James P Luyendyk Li Wang Grace L Guo

Farnesoid X receptor (FXR, Nr1h4) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR is essential in maintaining bile acid (BA) homeostasis, and FXR(-/-) mice develop cholestasis, inflammation, and spontaneous liver tumors. The signal transducer and activator of transcription 3 (STAT3) is well known to regulate liver growth, and STAT3 is feedback inhib...

2012
Jessica A. Williams Ann M. Thomas Guodong Li Bo Kong Le Zhan Yuka Inaba Wen Xie Wen-Xing Ding Grace L. Guo

BACKGROUND Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis. FXR is protective against carcinogenesis and inflammation in liver and intestine as demonstrated by the development of inflammation and tumors in the liver and intestine of FXR knock-out mice. However, me...

Journal: :Physiology 2008
Jyrki J Eloranta Gerd A Kullak-Ublick

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Yanqiao Zhang Florence Ying Lee Gabriel Barrera Hans Lee Charisse Vales Frank J Gonzalez Timothy M Willson Peter A Edwards

Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose metabolism. Activation of FXR by the synthetic agonist GW4064 or hepatic overexpression of constitutively active FXR by adenovirus-mediated gene transfer significantly lowered blood glucose levels in both diabetic db/db and wild-type mice. ...

Journal: :The Journal of biological chemistry 2010
Mouaadh Abdelkarim Sandrine Caron Christian Duhem Janne Prawitt Julie Dumont Anthony Lucas Emmanuel Bouchaert Olivier Briand John Brozek Folkert Kuipers Catherine Fievet Bertrand Cariou Bart Staels

The bile acid receptor farnesoid X receptor (FXR) is expressed in adipose tissue, but its function remains poorly defined. Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipocyte differentiation and function. The aim of this study was to analyze the role of FXR in adipocyte function and to assess whether it modulates PPARγ action. Therefore, we tested the respons...

2017
Ting Zheng Ju-Hee Kang Jung-Sun Sim Jung-Woo Kim Jeong-Tae Koh Chan Soo Shin Hyungsik Lim Mijung Yim

Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. Since the role of FXR in osteoclast differentiation remains ill-defined, we investigated the biological function of FXR on osteoclastogenesis, using FXR-deficient mice. We demonstrated that FXR deficiency increases osteoclast formation in vitro and in vivo. First, FXR def...

2011
Rian M. Nijmeijer Raffaella M. Gadaleta Saskia W. C. van Mil Adriaan A. van Bodegraven J. Bart A. Crusius Gerard Dijkstra Daan W. Hommes Dirk J. de Jong Pieter C. F. Stokkers Hein W. Verspaget Rinse K. Weersma C. Janneke van der Woude Janneke M. Stapelbroek Marguerite E. I. Schipper Cisca Wijmenga Karel J. van Erpecum Bas Oldenburg

BACKGROUND We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and colon of inflammatory bowel disease (IBD) patients in remission. Additionally, we evaluated wheth...

Journal: :Molecular endocrinology 2001
H R Kast C M Nguyen C J Sinal S A Jones B A Laffitte K Reue F J Gonzalez T M Willson P A Edwards

The farnesoid X-activated receptor (FXR; NR1H4), a member of the nuclear hormone receptor superfamily, induces gene expression in response to several bile acids, including chenodeoxycholic acid. Here we used suppression subtractive hybridization to identify apolipoprotein C-II (apoC-II) as an FXR target gene. Retroviral expression of FXR in HepG2 cells results in induction of the mRNA encoding ...

2012
Ulrich Deuschle Julia Schüler Andreas Schulz Thomas Schlüter Olaf Kinzel Ulrich Abel Claus Kremoser

The farnesoid X receptor (FXR) is expressed predominantly in tissues exposed to high levels of bile acids and controls bile acid and lipid homeostasis. FXR(-/-) mice develop hepatocellular carcinoma (HCC) and show an increased prevalence for intestinal malignancies, suggesting a role of FXR as a tumor suppressor in enterohepatic tissues. The N-myc downstream-regulated gene 2 (NDRG2) has been re...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2009
Pilar Martínez-Fernández Loreto Hierro Paloma Jara Luis Alvarez

Farnesoid X receptor (FXR) is a bile acid-sensing nuclear receptor that controls bile acid homeostasis. It has been suggested that downregulation of FXR contributes to the pathogenesis of an inherited disorder of bile secretion caused by mutations in ATP8B1. We have investigated the relationship between ATP8B1 knockdown and FXR downregulation in the human hepatoblastoma cell line HepG2. Transfe...

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