Background FOLFIRINOX (FX) has been reported as an effective treatment for unresectable advanced pancreatic cancer. However, FX is associated with a high incidence of adverse events (AEs). A previous phase II study in Japan showed high incidences of hematological AEs, including febrile neutropenia (22.2%). A modified FX regimen (mFX) may decrease the rates of AEs and be more effective than FX b...

a) 0 = FX,Y (−∞, y) = S(FX(−∞), FY (y)) = S(0, v) where v ∈ Ran FY , and analogously S(u, 0) = 0 for u ∈ Ran FX . b) FY (y) = FX,Y (+∞, y) = S(FX(+∞), FY (y)) = S(1, v) where v = FY (y), and analogously S(u, 1) = u where u = FX(x) for some x ∈ R. c) 0 ≤ P (x1 < X ≤ x2 , y1 < Y ≤ y2) = FX,Y (x2, y2)−FX,Y (x2, y1)−FX,Y (x1, y2)+ FX,Y (x1, y1) and therefore by (1) we have that S(u2, v2)− S(u2, v1)...

This paper examines the effectiveness of explicit and implicit foreign exchange (FX) interventions in New Zealand: one secret spot market intervention two – a regular Monetary Policy Statement (MPS) an unexpected oral by Reserve Bank Zealand (RBNZ) governor addressing Dollar (NZD). By applying synthetic control methodology to unique dataset RBNZ interventions, we construct counterfactual estima...

In this paper, we try to solve the valuation of currency option in financial engineering. We use a generalized jump-diffusion system to describe the spot Foreign Exchange (FX) rate and apply regime switching model to describe the domestic and foreign risk-free interest rate and the appreciation rate and the volatility. And the regime switching model is based on a continuous time finite state Ma...

We analyze the connections between the credit spreads that the same credit risk commands in different currencies. We show that the empirically observed differences in these credit spreads are mostly driven by the dependency between the default risk of the obligor and the exchange rate. In our model there are two different channels to capture this dependence: First, the diffusions driving FX and...

In this paper, a filtered-x recursive least squares (FX-RLS) algorithm based on adaptive 3rd-order Volterra filtering is proposed for nonlinear active noise control (ANC) of systems with a nonlinear primary acoustic path. The simulation results show that the proposed approach yields faster convergence, compared with the conventional methods (e.g., FX-NLMS and FX-GSPAP), for the nonlinear ANC. K...

Hepatocyte transduction following intravenous administration of adenovirus 5 (Ad5) is mediated by interaction between coagulation factor X (FX) and the hexon. The FX serine protease (SP) domain tethers the Ad5/FX complex to hepatocytes through binding heparan sulfate proteoglycans (HSPGs). Here, we identify the critical HSPG-interacting residues of FX. We generated an FX mutant by modifying sev...

For a metric space&nbsp;$X$, let $\mathsf FX$ be the space of all non-empty finite subsets $X$ endowed with largest $d^1_{\mathsf FX}$ such that for every $n\in \mathbb N $ map $X^n\to \mathsf FX$, $(x_1,\ldots ,x_n)\mapsto \{x_1,\ldots