This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF...

Aim: The aim of periodontal surgery is complete regeneration. The present study was designed to evaluate and compare clinically soft tissue changes in form of probing pocket depth, gingival shrinkage, attachment level and hard tissue changes in form of horizontal and vertical bone level using resorbable membranes. Materials and methods: Twelve subjects with bilateral class 2 furcation defects w...

the purpose of the present randomized clinical trial study was to compare the effectiveness of bovine porous bone mineral (bpbm) with and without plasma rich in growth factors (prgf) in the treatment of mandibular class ii furcation defects.in seven patients, nine pairs of symmetric buccal or lingual mandibular class ii furcation defects were treated. in each patient, one defect received bpbm (...

Introduction: Clinicians tend to encounter unfavorable situations in the treatment of teeth with severe attachment loss. Periodontal regeneration has been a successful therapeutic approach treatments that require long-term prognosis improvement. This case shows benefits combined regenerative periodontal therapy patient molar severely compromised by furcation, intrabony defects and loss apex. Ca...

We recently demonstrated that a topical application of basic fibroblast growth factor (FGF-2; bFGF) to alveolar bone defects in beagle dogs enhanced periodontal regeneration. The purpose of this study was further characterization of the biological effects of FGF-2 in non-human primates. Thirty-two inflamed furcation class II defects were surgically created in 4 male primates. The gelatinous car...

BACKGROUND Successful treatment of molar furcation defects remains a challenge in clinical practice. Knowledge of anatomic factors facilitates predictable management of furcation involvement lesions. The degree of success in managing furcation involvement is inversely related to the horizontal probing depth. The depth of the horizontal component of attachment loss can vary depending on the exte...

OBJECTIVES To explore the diagnostic values of digital intraoral radiography and cone beam CT (CBCT) in the determination of periodontal bone loss, infrabony craters and furcation involvements. METHODS Accuracy assessment of the imaging modalities was conducted through bone level measurements, infrabony crater and furcation involvement classifications. For CBCT, images were obtained at 120 kV...

context this article reviews the available evidence about the barrier membranes utilized in guided tissue regeneration process to prevent the migration of unfavorable cells to the wound area. evidence acquisition available evidence about membranes properties and their different uses were reviewed, and the results of clinical and animal studies and systematic reviews were gathered. results a lar...