PURPOSE Fusarium, Aspergillus, and Dematiaceous are the most common fungal species causing keratitis in tropical countries. Herein we report a prospective study on fungal keratitis caused by these three fungal species. METHODOLOGY A prospective investigation was undertaken to evaluate eyes with presumed fungal keratitis. All the fungal isolates (n = 73) obtained from keratitis infections were...

CLINICAL QUESTION What is the most appropriate management of fungal keratitis? RESULTS Traditionally, topical Natamycin is the most commonly used medication for filamentous fungi while Amphotericin B is most commonly used for yeast. Voriconazole is rapidly becoming the drug of choice for all fungal keratitis because of its wide spectrum of coverage and increased penetration into the cornea. ...

PURPOSE The aim of this study was to develop and characterize a new contact lens-associated fungal keratitis rat model and to assess the ability of non-invasive spectral-domain optical coherence tomography (SD-OCT) to detect pathological changes in vivo in fungal keratitis. METHODS We used SD-OCT to image and measure the cornea of Sprague Dawley rats. Fusarium infection was initiated in the r...

Purpose To report two rare cases of filamentous fungal keratitis. Methods Two non-consecutive patients presented with suspicious fungal keratitis. After performing the smear and culture, medical therapy was started for them. They underwent slit photography and in vivo confocal microscopy (IVCM) in their follow-up visits. Results The patients were 33-year-old and 56-year-old farmer men. They...

PURPOSE Mycotic keratitis is a major cause of corneal blindness in India. A proper understanding of the pathogenesis may help in refining the existing treatment. The purpose of this study is to examine the total tear protein profile of fungal keratitis patients, which may have a bearing on pathogenesis and disease progression. METHODS Tear samples were collected from culture positive fungal k...

However, some cases of keratitis result from unknown factors. Generally, more than 70 genera of filamentous fungi and yeast have been identified in fungal keratitis. The predominant causes of fungal keratitis are Aspergillus, Acremonium, Penicillium and Fusarium solani which are all non-pigmented fungi. Although Fusarium and Aspergillus clearly dominate the list, causative agents vary in differ...

Background: Fungal keratitis is an acute or chronic inflammation of the cornea caused by fungi. The main treatment for fungal Natamycin 5%. Disadvantages natamycin are its poor penetration and increased resistance due to fungi which lower level ergosterol in wall. Purpose: Investigates effect bromelain, zingibain papain on LOX-1 receptors Aspergillus fumigatus. Result: receptor with bromelain p...

Fungal keratitis is one of the major causes of ophthalmic mycosis and is difficult to treat. The range of common antifungal agents available for fungal keratitis remains inadequate and is generally associated with poor clinical outcomes. Voriconazole is a new generation triazole antifungal agent. Only marketed in systemic formulation and, with broad-spectrum activity and high intraocular penetr...

PURPOSE Fungal keratitis is a severe sight-threatening condition. The aim of this study was to investigate the incidence and clinical characteristics of fungal keratitis patients living in a temperate climate. METHODS By reviewing medical records from 2000 to July 2013, patients with fungal keratitis were identified. Risk factors, clinical signs and outcome were registered. RESULTS Twenty-f...

Fungal keratitis is an infection of the cornea by fungal pathogens. Diagnosis methods based on optical microscopy could be beneficial over the conventional microbiology method by allowing rapid and non-invasive examination. Reflectance confocal microscopy (RCM) and two-photon second harmonic generation microscopy (TPSHGM) have been applied to pre-clinical or clinical studies of fungal keratitis...