Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipidmatrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

in order to achieve prolong corneal contact time of norfloxacin(nfx) for treatment of extra ocular diseases, a ph triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. nfx loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

The computerization of method development and validation are useful in analysis of pharmaceuticals in pharmaceutical industry. In this article a simple and rapid high performance liquid chromatographic method has been developed for the determination of oxcarbazipine in pharmaceutical formulations. Factorial design was applied for optimization of essential factors for robustness study. A linear ...

The combination of lab automation and design experiments for the execution screening increases productivity reduces error-prone manual work. A self-developed software tool allows creating fractional-factorial experimental (FFED). Application FFED on a Suzuki-Miyaura cross-coupling leads to 93 % reduced compared full-factorial design. resulting regression model qualitatively shows positive effec...

The purpose of the study is to assess the applicability of full factorial experimental design in predicting the ballistic strength of glass fiber/phenolic ballistic composites. In the study we used a number of ballistic composites (20 cm x 20 cm) with different thickness and fiber/resin ratio. The composites were made by an open mold high pressure, high-temperature compression of prepreg layers...