Software vendors often need to vary their products to satisfy customer-specific requirements. In many cases, existing code is reused and adapted to the new project needs. This copy&paste course of action leads a multiproduct code-base that is hard to maintain. Software Product Lines (SPL) emerged as an appropriate concept to manage product families with common functionality and code bases. Evol...

Overview. Neurologists are frequently called upon to evaluate patients with vertigo and dizziness and, in some cases, to make sense of abnormal vestibular tests. Consequently, it is useful to have some familiarity with the methods used to test vestibular function. The vestibulo-ocular reflex (VOR) is a reflex that acts at short latency to generate eye movements that compensate for head rotation...

Information about population age structures is useful to understand survival rates, longevity, and population turnover. However, little such information is available about wolf (Canis lupus) populations. Mech (1970) estimated age structures of wolf-population age structure from pup:adult ratios applying various demographic assumptions, but no direct information has been published to test his es...

This study investigates the role of surface waves and the associated disturbance of littoral sediments for the release and later distribution of dissolved methane in lakes. Surface wave field, wave-induced currents, acoustic backscatter strength, and the concentration and distribution of dissolved methane were measured simultaneously in Lake Constance, Germany. The data indicate that surface wa...

Neuroblastoma is the most common and aggressive extracranial solid tumor during childhood. MYCN-amplification is found in approximately 25 % of all neuroblastoma cases, and is defined as high-risk disease. Development of novel therapeutic approaches focused on MYCN targeting are essential for increased survival these children. The MYC family of oncoproteins consists of transcriptional factors i...

Introduction: PRT1419 is a potent and selective inhibitor of myeloid cell leukemia-1 (MCL-1). MCL-1 frequently amplified or overexpressed in hematologic malignancies associated with higher grade malignancy poor prognosis (Xiang et al., Onco Targets Ther 2018). Azacitidine (AZA) treatment was shown to induce several proapoptotic changes primary acute leukemia (AML) isolates, including decrease p...

Morgan, P. J., Nanoff, C., Strosberg, A. D., and Jockers, R. (1999). Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. Mol. Endocrinol. 13, 2025–2038. Ersahin, C., Masana, M. I., and Dubocovich, M. L. (2002). Constitutively active melatonin MT1 receptors in male rat caudal arteries. Eur. J. Pharmacol. 439, 171–172. Hunt, A. E., Al-Ghoul, W. M., Gillette, ...

The kinetics of microbial amorphous Fe(III) oxide reduction was investigated in sediments from a freshwater wetland in north central Alabama, USA. Fe(III) oxide concentrations decreased exponentially with time during anaerobic incubation of sediment slurries and homogenized surface sediments. Rates of organic carbon mineralization (SCO2 1 CH4 accumulation) did not change markedly during the cou...

We present a case of torsional saccadic oscillations and discuss the possible underlying neuroanatomical substrate. Correspondence to: Marcello Cherchi, M.D., Ph.D., Ken and Ruth Davee Department of Neurology, Northwestern Feinberg School of Medicine, Abbott Hall, 11th Floor, 710 N. Lake Shore Drive, Chicago, IL 60611-3078, USA, Tel: 312-908-8266; E-mail: [email protected] Received...