Nearly 50% of patients with multiple myeloma develop renal disease, most commonly from AKI caused by cast nephropathy. Development of AKI is associated with poor 1-year survival and reduces the therapeutic options available to patients. There is a great need for more effective therapies. Cast nephropathy is caused by the interaction and aggregation of filtered free light chains and Tamm-Horsfal...

Physical, chemical, and immunological properties and association-dissociation behavior of various molecular forms of free normal light chains of human immunoglobulin have been examined. Free light chains were isolated from the urine of both normal individuals and patients with tubular proteinuria by means of ultratlltration, zone electrophoresis, gel chromatography, and ion exchange chromatogra...

Comparison of free κ and λ light chain immunoassays and total (bound and free) κ and λ light chain immunoassays To the editor: We read, with interest, the article by Dr. Zamora-Ortiz, et al. Poor performance of the total kappa/ lambda light chain quantification in the diagnosis and follow-up of patients with multiple myeloma on the comparison of the total serum light chain assay (sLC), SPE and ...