UNLABELLED Over the last decade, immunoinformatics has made significant progress. Computational approaches, in particular the prediction of T-cell epitopes using machine learning methods, are at the core of modern vaccine design. Large-scale analyses and the integration or comparison of different methods become increasingly important. We have developed FRED, an extendable, open source software ...

The Tamagawa number conjecture of Bloch and Kato describes the behavior at integers of the L-function associated to a motive over Q. Let f be a newform of weight k ≥ 2, level N with coefficients in a number field K. Let M be the motive associated to f and let A be the adjoint motive of M . Let λ be a finite prime of K. We verify the λ-part of the Bloch-Kato conjecture for L(A, 0) and L(A, 1) wh...

There are two reasons for s tudying the possible role of the Epstein-Barr virus (EBV) in relation to rheumato id arthritis (RA). The first is the recent demonstrat ion by Alspaugh and co-workers that EBV infection o f normal peripheral blood lymphocytes induces the development in these cells of a nuclear antigen against which most patients with RA have precipitat ing antibodies (I). The second ...

Summarizing Fred’s contributions to mathematics in a 1–hour talk, or for that matter in a single paper, is a daunting task. With nearly a hundred papers in print, and collaborations with no less than 48 authors, the sheer volume of his publication record makes trying to choose the appropriate highlights a difficult task. What makes it even harder is the variety of topics the work touches on. To...

The proposal is stated it its entirety in the plan that you reference. Initially, as you know, I was discussing the notion of a carbon tax on transportation fuels. As the discussion, both at the commission meetings and in general, moved along, I was convinced by Severin Borenstein (who testified before the commission on this notion, Joe Bankman at Stanford, Dan Simmons at UC, and John Boesel at...

This paper presents the FRED system, a development environment for agent-based applications that utilize Semantic Web resources. The FRED system consists of an agent runtime environment based on ontologies as the underlying data model and offers a tool suite for application development. It uses progressive technologies for task-service-resolution that detect suitable problem solving implementat...

In this special Focus Issue on Stomata, it is only fitting to pay tribute to one of the stomatal development field’s founders and greatest champions, Fred David Sack (1947–2015). Fred was born in New York City and raised in a progressive tradition that valued an understanding and appreciation of the human and scientificworlds. Fred attended Stuyvesant High School and Antioch College, where he m...

Fred Fay died unexpectedly at 53 years of age while working with colleagues in Germany. Fred spent most of his career at the University of Massachusetts Medical School where he had been one of the founding faculty members. His biological interests were the contractile mechanisms of smooth muscle and chemotaxis, but Fred’s greatest enthusiasm was for instrumentation. Fred invented new ways to se...

Can cloud cover on Election Day be used to predict the next governor? What can college football games tell us about the next presidential race? These are questions that motivate Fred Wolens, a junior in the Political Science department, in his ongoing research on Retrospective Voter Theory. Retrospective Voter Theory assumes that voters will choose to re-elect—or not to re-elect—an incumbent ba...

This document specifies a method for connecting IPv6 hosts and routers (nodes) within predominantly IPv4-based sites. This method is based on an IPv6-IPv4 compatibility aggregatable global unicast address format (described herein) that embeds the IPv4 address of a node within the EUI-64 format interface identifier of an IPv6 address. This document assumes that, during the IPv4 to IPv6 coexisten...