multiple myeloma (mm) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. recently, arsenic trioxide (ato), has been considered for treatment refractory mm. we assessed the safety and efficacy of ato for patients with refractory mm. a phase 2, study of arsenic trioxide was conducted in 12 mm patients, whose refractory to two standard ther...

background there is the controversy concerning the main component of tobacco, which is responsible for its arrhythmogenesis. in addition, there is the lack of adequate information about the influence of combination of black tea and nicotine on heart rhythm. objectives this study aimed to examine whether pretreatment with black tea and nicotine could modulate the susceptibility to lethal ventric...

BACKGROUND The strong link between sealer solubility and periapical reinfection indicates that water solubility of new sealers should be studied. This study aimed to assess the water solubility of five root canal sealers (AH-26, Topseal, 2-Seal, Acroseal, and Roeko Seal Automix [RSA]). MATERIALS AND METHODS In this in vitro experimental study, 30 specimens were fabricated from each of the abo...

This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given ...

PURPOSE Ridaforolimus is an investigational, potent, selective mTOR inhibitor. This study was conducted to determine the recommended phase 2 dose (RP2D), maximum tolerated dose, safety, pharmacokinetics, and antitumor activity of oral ridaforolimus in children with advanced solid tumors. EXPERIMENTAL DESIGN In this phase 1, multicenter, open-label study in children aged 6 to <18 years with ad...

There is an aura about sessions such as this which suggests analogies to a fraternity initiation. Given that, one of the first questions the discussant must ask himself is where his discussion stands in relation to "Hell Week." All of us, I believe, would agree that "Hell Week" is the responsibility of the pledge trainer, or dissertation adviser in this case. If "Hell Week" is over, is the disc...

National Vocational Qualifications (NVQs) were developed out of a plethora of initiatives implemented between 1960 and 1990. The format of NVQs was initially based on a hierarchical task analysis of job functions within the hospitality and catering industry, conducted as part of the CATERBASE project, which was commissioned by the Manpower Services Commission in the mid-1980s. This issues paper...