Non-valvular atrial fibrillation (NVAF) is a common form of cardiac arrhythmia that affects 1–1.5% adults and roughly 10% elderly with dysphagia. Apixaban an anticoagulant referred to as factor Xa inhibitor, which has been shown reduce the risk stroke systemic embolism in cases NVAF. Our objective current study was formulate orally disintegrating film facilitate administration apixaban patients...

A parametric formulation for preliminary design of tubed-system tall buildings is presented in which some optimality criteria and practical constraints are considered. Here, a minimum compliance optimization formulation, developed by other researchers, is applied to a framed-tube structure. The tube behavior is modeled as a cantilevered box beam. Independent variable in this problem is thicknes...

Laid down in this paper are the foundations on which the design of engineering systems, in the presence of an uncontrollable changing environment, can be based. The changes in environment conditions are accounted for by means of robustness. To this end, a theoretical framework as well as a general methodology for model-based robust design are proposed. Within this framework, all quantities invo...

In this paper, a BB algorithm is used to designed structured controller that minimizes a matching model criteria. This non convex optimization problem is formulated as a BMI problem with additional variables allowing lower and upper bound estimation by LMI subproblems. A reduction of the additional variables is proposed to reduce the computation time. To demonstrate the effectiveness of the app...

Case-Based Design (CBD) applies a knowledge-based process to the knowledge commonly associated with Case-Based Reasoning (CBR) systems { the library of exemplars. This paper investigates the problems in using commercial CBR tools, primarily aimed at classi cation applications, for a more knowledge intensive CBD task, and proposes techniques that overcome some of these di culties. This work resu...

The drivers to produce solid solution formulations are reviewed together with specific challenges of implementing extrusion in a pharmaceutical setting. A solvent-based approach to screen formulations with less than 10 mg drug/screen is introduced and validated with experimental data. Process development challenges associated with the use of hygroscopic fine polymer powders are addressed throug...

Advances in molecular biology, and of physiological and disease processes, often identify opportunities for improving the performance of a medication. Performance enhancement might concern providing more options for administration, less frequent administration or simply providing medication that is more acceptable to the user. Possibilities also exist, depending on the kinetics and dynamics of ...