Through a novel sequence of aminodiene Diels-Alder reactions, amidofurans 18a-c were converted to tricyclic ketones 21a-c in moderate to good yields. Ketone 21a could be converted to Uhlé's ketone (6) by cleaving the tert-butyl carbamate and oxidatively removing the methyl ester. Tricycle 21a readily underwent bromination to give 22. Formation of the corresponding enol triflate 25 followed by c...

There is now no doubt that ketone bodies (acetoacetate and D-3-hydroxybutyrate) are important oxidizable substrates for peripheral tissues, especially the brain. Although oxidation is the major fate of ketone bodies, more recent evidence suggests that ketone bodies can act as lipogenic substrates in certain tissues, notably the developing brain and the lactating mammary gland. Apart from their ...

backgrounds: subclinical ketosis can cause greater economic loss due to a lack of clinical symptoms. objectives: the present study was aimed to design a chemical method for measuring serum ketone bodies in the affected subclinical cows. methods: acetoacetate concentrations were measured using a nitroprusside reaction and b-hydroxy butyric acid (bhba) which was oxidized to acetoacetate using nan...

One series of half-analogues of Michler’s ketone containing one or more terminal methoxysubstituents with variable tertiary amino groups have been used in this study. NMR spectralresults for the parent ketones confirm earlier findings that ortho proton shifts are apparentlyindependent from steric effects in derivatives of Michler’s ketone because the ring current andcarbonyl-induced shifts are ...

In this study, NRTL and UNIQUAC thermodynamic models were used to predict the composition of ternary mixtures of solvents+ m/o/p-cresol+ water in organic and aqueous phases. Various solvents are used for the separation of cresols from water. In this study, methyl propyl ketone, methyl isopropyl ketone, methyl butyl ketone, and methyl isobutyl ketone solvents were investigated. Intermolecular in...

Until recently the views prevalent in the literature with respect to ketone formation in the normal and diabetic organism were as follows: The long fatty acid carbon chains are split by successive /3 oxidation, 2 carbons at a time, with the formation of intermediate shorter fatty acids and acetic acid (Knoop hypothesis). Normally this process continues to completion, but in the absence of suffi...

The concentrations of malonyl-CoA, citrate, ketone bodies and long-chain acylcarnitine were measured in freeze-clamped liver samples from fed or starved normal, partially hepatectomized or sham-operated rats. These parameters were used in conjunction with measurements of the concentration of plasma non-esterified fatty acids and the rates of hepatic lipogenesis to obtain correlations between ra...

Silica Vanadic Acid, SVA, (oxo-vanadium has been supported on silica) as a dual Lewis and Bronsted acid ability was prepared and efficiently catalyzed one-pot multi-component condensation of enolizable ketones or alkyl acetoacetates with aromatic aldehydes, acetonitrile and acetyl chloride. The described reaction was produced β-acetamido ketone or ester derivatives in high to excellent yields i...