1970年,北 海 道 にHand,foot and mouth disease の 大 き な流 行 の あつ た 際 に,Coxsackie A 16と こ の ウ イル ス 以外 にCoxsackie Aウ イ ル ス が分 離 され た. これ らの うち,帯 広,旭 川,札 幌 の3地 区 の 患者153 名 か ら,サ ル 腎 初 代 培 養 細 胞 に よつ てCoxsackie A 16 が79株(51.6%),未 同定 の ウイ ル ス が25株(16.3%) が分 離 され た. 一 方 ,同 一 被 検 体 を 哺 乳 マ ウス接 種 に よつ て,Coxsackie A 16が61株(39.9%)分 離 され た ほ か に,Coxsackie A4が17株(11.1%),A5が27株(17.6%),A6 が63株(41.2%),A10が9株(5.9%)が 分...

Control and prevention of foot and mouth disease (FMD) by vaccination remains unsatisfactory in endemic countries. Indeed, consistent and new FMD epidemics in previously disease-free countries have precipitated the need for a worldwide control strategy. Outbreaks in vaccinated animals require that a new and safe vaccine be developed against foot and mouth virus (FMDV). FMDV can be eradicated wo...

INTRODUCTION Hand, foot and mouth disease (HFMD) caused by EV71 infection has become one of the major public health issues in China, which deeply affects children's health. The prevention and control of EV71 is a challenge currently because there is no safe and effective vaccine or antiviral medications available. MATERIAL AND METHODS A case control study was conducted in a designated hospita...

Complement-fixation patterns were established for four subtypes of foot-and-mouth disease virus by block assays against homologous and heterologous antiserum. Inhibition of fixation by excess antigen was observed in most homologous systems but rarely in the heterologous systems. The heterologous antibody titers were, in all instances, considerably lower than those for the homologous systems. Al...

In order to tackle both regional and global foot-and-mouth disease virus (FMDV) epdimics, we hereby develop a rapid microfluidic thermal lens microscopic method to screen swine type O FMDV with good efficiency. The scheme has great merits in terms of field portability, sample volume, assay time, analytical sensitivity, and test reproducibility.

Sequencing and subsequent analysis of a vaccine strain of foot-and-mouth disease virus serotype O is reported here. Genomic heterogeneity in the protective epitopes (VP1 protein) of the reported strain, compared to characterized strains and available sequences from Pakistan, warrants further studies to determine vaccine-induced immunity and disease protection.

A microneutralization test for foot-and-mouth disease virus antibodies is described and compared to the standard mouse test.

BACKGROUND Hand, foot and mouth disease (HFMD) is a rising public health issue in the Asia-Pacific region. Numerous studies have tried to quantify the relationship between meteorological variables and HFMD but with inconsistent results, in particular for temperature. We aimed to characterize the relationship between temperature and HFMD in various locations and to investigate the potential hete...

Synthetic 2-stranded RNA-a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)-induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of p...