BACKGROUND Increasing interest in sublingual immunotherapy (SLIT) among practitioners and patients has resulted in numerous publications and clinical trials in recent years. With the clinical growth of SLIT, discussions of its efficacy, safety, and immunologic effects have intensified, as have comparisons to subcutaneous immunotherapy (SCIT). In the United States, SCIT has been the traditional...

BACKGROUND In the last decade the use of different types of oral immunotherapy for food-allergic patients has increased with generally satisfactory outcomes. Cow's milk and hen's egg, a common element in the daily diet, have received the main interest. Most of these immunotherapy regimens are performed in the hospital, causing inconvenience for both children and their parents. OBJECTIVES To a...

BACKGROUND Peanut immunotherapy studies are conducted with the aim to decrease the sensitivity of patients to peanut exposure with the outcome evaluated by testing the threshold for allergic response in a double-blind placebo-controlled food challenge. The clinical relevance of increasing this threshold is not well characterized. OBJECTIVE We aimed to quantify the clinical benefit of an incre...

although food allergy is a major public health problem, currently there is no effective and safe treatment except to avoid the foods .but the need for new options is critical now as the number of children diagnosed with food allergies rises. avoiding the offending allergen in the diet is the primary treatment of food allergy. once a food to which the patient is sensitive has been identified, th...

BACKGROUND Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients. METHODS Patients with both ulcerative colitis (UC) and food allergy were recruited into this study. Food allergy was diagnosed by skin prick test and serum specific IgE. The p...

Allergic asthma as a complex outcome of pathogenic immunological, cellular and functional modifications of the airways is initiated by allergic reactions as a response mostly to inhalant allergens. Dysregulation of innate and adaptive immune functions contribute to the pathogenesis of the disease. A hallmark is the development of a Th2-driven inflammatory response in the airways. The underlying...