Ethylene glycol (EG) dan diethylene (DEG) adalah senyawa alkohol toksik berbentuk cairan dengan rasa manis; ini dapat ditemukan di beberapa alat rumah tangga, zat antibeku, pelarut automotif industri. Keracunan akibat konsumsi bisa fatal. EG DEG merupakan keadaan darurat medis yang membutuhkan diagnosis segera pengobatan agresif meliputi terapi suportif, antidot fomepizole atau ethanol, hemodia...

Ethylene glycol (EG) and methanol poisoning can cause life-threatening complications. Toxicity of EG and methanol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), which can lead to metabolic acidosis, renal failure (in EG poisoning), blindness (in methanol poisoning) and death. Therapy consists of general supportive care (e.g. intravenous fluids, corr...

Poisoning is an uncommon but potentially fatal outcome of toxic alcohol ingestion. The toxic alcohols methanol, ethylene glycol and isopropyl alcohol are commonly found in household and commercial products. Because the toxic effects are caused by the metabolites of methanol and ethylene glycol rather than the agents themselves, there is often a substantial delay between ingestion and onset of c...

INTRODUCTION Every year about 2.4 million people in USA are exposed to toxic substances. Many of them are children below 6 years of age. Majority of poisonings in children are incidental and related to household products including for example drugs, cleaning products or antifreeze products. Antifreeze solutions contain ethylene glycol and methanol. Treatment of these toxic substances involves e...

A 64-year-old man with no significant medical history was admitted to the intensive care unit with a progressive visual abnormality and he was also in a coma. Because of a rapid exacerbation of his symptoms and the onset of severe metabolic acidosis, we treated him with fomepizole due to suspected methanol intoxication, however, he never recovered from the coma. An extremely high concentration ...

Poisonings from toxic alcohols, such as methanol (MeOH) are a serious toxicological concern worldwide. In an endemic methanol poisoning in 2012 in the Czech Republic 121 subjects had consumed adulterated beverages and 41 died from the poisoning. An additional 20 subjects still suffer from visual/CNS sequelae [1]. In addition to mass poisonings single cases of methanol poisoning had been publish...

Methanol (MeOH) is a toxic alcohol present in many solvents and antifreeze solutions. Ingested MeOH undergoes enzymatic oxidation to toxic formic acid, resulting in acidosis, neurotoxicity and death in severe poisoning. Treatment relies on antidote administration (fomepizole or ethanol) to antagonize MeOH oxidation, folic acid to facilitate the catabolism of formic acid, correction of acidosis ...