Khosrow Adeli Clinical Biochemistry, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 1X8 Canada List of abbreviations: CALIPER, Canadian Laboratory Initiative on Pediatric Reference Intervals; RIDL, Reference Intervals and Decision Limits; IFCC, International Federation of Clinical Chemistry and Laboratory Medicine; CLSI, Clinical Laboratory Standards Institute; GGT...

Background Anti-Müllerian hormone (AMH) is secreted by the granulosa cells of growing follicles during the primary to large antral follicle stages. Abnormal levels of AMH and follicle stimulating hormone (FSH) may indicate a woman’s diminished ability or inability to conceive. Our aim is to investigate the changes in serum AMH and FSH concentrations at different age groups and its correlation w...

background: diabetic men have been claimed to have lower serum free testosterone (ft) concentrations than non-diabetic men. the aim of this study was to investigate if serum ft, luteinizing hormone (lh), and follicle stimulating hormone (fsh) concentrations are different in patients with type 2 diabetes mellitus compared with healthy men and to identify factors associated with low serum testost...

Aims: To evaluate the ovarian reserve in women with chronic urticaria (CU).
 Methods: Thirty CU and twenty nine healthy controls were enrolled this study. Serum levels of anti-Müllerian hormone (AMH), follicle-stimulating (FSH), estradiol (E2), luteinizing (LH) measured on cycle day 2. All patients underwent transvaginal ultrasonographic examination second their menstrual to assess Antral ...

introduction: follicle stimulating hormone (fsh) is one of the pituitary glycoproteines that it consists of two subunits alpha and beta. the beta subunit is responsible for the biological activity of fsh. the aim of present study was isolation of the β subunit coding sequence containing its signal sequence from human genome and then cloning of the isolated sequence in ppic9 shuttle vector under...

Follicle-stimulating hormone (FSH) plays a central role in mammals reproduction, with the actions of FSH mediated by follicle-stimulating hormone receptors (FSHRs) on the surface of target cells. The purposes of this study were to determine and evaluate the biological activities for the commercialization of recombinant folliclestimulating hormone (rFSH) in vitro through the cellular internaliza...

In the normal human menstrual cycle, the final phase of ovarian folliculogenesis leading upto the pre-ovulatory stage is gonadotropin dependent. Luteinising hormone (LH) acts synergistically with follicle stimulating hormone (FSH) to achieve follicular steroidogenesis, luteinisation and ovulation. It therefore follows that the maturational process of the oocyte contained within the follicle and...

The CAMP-dependent protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) inhibitor in Sertoli cell-enriched rat testis has been shown to be specifically stimulated by follicle-stimulating hormone in uiuo. Intraperitoneal injection of follicle-stimulating hormone (100 pg of NIH-FSH-S12) induced a significant increase in protein kinase inhibitor 8 h after injection. Maximal stimulation of ...

INTRODUCTION Our aim was to evaluate the predictive values of factors that indicate successful sperm retrieval in men with nonobstructive azoospermia. MATERIALS AND METHODS We evaluated 85 infertile men with nonobstructive azoospermia who underwent multiple bilateral testicular biopsies. Factors including age, infertility period, surgical history, testicular volume, testicular consistency, se...

In the normal human menstrual cycle, the final phase of ovarian folliculogenesis leading upto the pre-ovulatory stage is gonadotropin dependent. Luteinising hormone (LH) acts synergistically with follicle stimulating hormone (FSH) to achieve follicular steroidogenesis, luteinisation and ovulation. It therefore follows that the maturational process of the oocyte contained within the follicle and...