نتایج جستجو برای: fok1 polymorphism

تعداد نتایج: 107356  

Journal: :Anticancer research 2013
Barbara J Fuhrman D Michal Freedman Parveen Bhatti Michele M Doody Yi-Ping Fu Shih-Chen Chang Martha S Linet Alice J Sigurdson

BACKGROUND/AIM Geographic gradients in breast cancer incidence and mortality suggest that vitamin D may reduce risk. The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. We investigated six polymorphisms in CYP24A1 and two in the VDR gene in association with breast cancer risk. M...

Journal: :Carcinogenesis 2007
Jiali Han Graham A Colditz David J Hunter

Folate and vitamin D have been shown to be influenced by ultraviolet (UV) radiation. UVA radiation can break down plasma folate, whereas vitamin D can be synthesized in UVB-exposed skin. Folate metabolism is involved in DNA synthesis and repair, and vitamin D processes anti-proliferative effects. The functions of both nutrients are implicated in skin carcinogenesis. We evaluated genetic polymor...

2010
Azza A.G. Tantawy Eman A. El-Bostany Randa M. Matter Eman A. El-Ghoroury Shadia Ragab

INTRODUCTION Thalassaemic osteopathy is a multifactorial disorder and limited information exists about bone accrual and bone mineral density (BMD) in prepubertal thalassaemic children. The study aimed to investigate some potential genetic and biochemical bone markers as possible early predictors of BMD variations in children with β-thalassaemia major (TM) before puberty. MATERIAL AND METHODS ...

Journal: :Genes & diseases 2014
Hongmei Zhang Zhengjian Yan Melissa Li Michael Peabody Tong-Chuan He

tp://dx.doi.org/10.1016/j.gendis.2 52-3042/Copyright a 2014, Chongq Bacteria and archaea have been known for decades having evolvedadaptive immunedefenses calledclustered regularly interspaced short palindromic repeats (CRISPR)/CRISPRassociated (Cas) systems to degrade foreign nucleic acids. Recently, these RNA-guided Cas9 nucleases derived from CRISPR/Cas systems have shown promise in transfor...

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