Obesity and obesity-related diseases including insulin resistance metabolic syndrome (MetS) pose a great risk for cardiovascular development. Skeletal muscle as an endocrine organ has pivotal role on secreting physiological factors such hormones myokines. Irisin that is one of these miyokines also known hormone secreted mainly from tissue in response to exercise. It dependent fibronectin type I...

Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This ...

Background. Irisin is the result of the proteolysis of fibronectin type III domain-containing protein 5, the levels of which are determined by physical activity. Objective(s). This study aims to identify changes in FNDC5 gene expression and the heart muscle irisin levels in male rats following 8 weeks resistance and endurance training. Methods. Fifteen male rats (10-12 weeks old and 331.8&plu...

Introdution: Obesity is a systemic disorder that disruption the regulation of the effective proteins; in fat metabolism (Desnurtin, FNDC5 it leads to resistance to insulin and Diabetes.  The aim of this study was comparing the 6 weeks of high-intensity interval and continuous training with standard diet on desnutrin and FNDC5 genes expression in subcutaneous adipose tissue and the quadrice...

We are experiencing a worldwide epidemic of obesity and type II diabetes. Our group has been interested in the development of both white and brown fat, particularly at the level of gene transcription. PGC1a was first described as a coactivator of PPARg in the control of brown fatmediated thermogenesis. More recent work has shown that PGC1a controls much of an exercise program in skeletal muscle...