Introduction FMF is associated with pulmonary hypertension(PH) due to amyloidosis. However, clinically overt PH with right-sided heart failure remains a rare event limited to few patients with pulmonary amyloidosis secondary to FMF. We report two cases of FMF patients, with and without amyloidosis, who experienced PH with rightsided heart failure. To our knowledge, this is the first case report...

OBJECTIVE To determine urinary leukotriene B4 (LTB4) levels and their role in FMF: METHODS Urinary LTB4 levels were studied using a commercial ELISA kit in 12 FMF patients during abdominal attacks, and 20 FMF patients during remission. RESULTS Urinary LTB4 levels in FMF patients during attacks were comparable to those during remission, but higher than normal levels (p = 0.03). CONCLUSIONS...

Familial Mediterranean fever (FMF) is an autosomal, recessive disease affecting mainly people of Mediterranean origin. The primary pattern of FMF is acute, self-resolving periodic attacks of high-grade fever, accompanied by either peritonitis, pleuritis, or arthritis and sometimes typical ankle rash that simulates erysipelas. Rare manifestations, such as pericarditis or massive knee effusion, h...

OBJECTIVE To determine whether the 2 periodic febrile syndromes familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS) are distinct diseases. METHODS Clinical manifestations of the diseases were analyzed by physicians experienced with FMF and HIDS. Serum immunoglobulin (Ig) levels were studied in 70 patients with FMF using nephelometry or ELISA and compared with Ig l...

BACKGROUND AND OBJECTIVES We sought to validate the family medicine shelf examination by determining whether correlations exist between the US Medical Licensing Examination (USMLE) family medicine final examination (FMF) scores and the USMLE Step 1 or Step 2 scores. We also evaluated for correlations between the family medicine clinical evaluation scores (CES), final clerkship grades, and all o...

Objective: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent inflammatory febrile attacks of serosal and synovial membranes. Recently few studies have shown that FMF is associated with increased atherosclerosis risk. Therefore, this study was designed to answers the following questions: A) do von Willebrand factor (vWf )a marker of endothelial damag...

Introduction Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of fever and serositis. A relation between FMF and Ankylosing Spondylitis (AS) has been suggested in small cohort studies, although there is no consensus regarding the role of HLA B27. Colchicine, the mainstay treatment in FMF, does not improve the axial or peripheral symptoms due t...

Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent febrile polyserositis and arthritis attacks. Accompanying seronegative spondyloarthropathy has been reported in FMF in addition to its own joint involvement. However, the coexistence of FMF with juvenile idiopathic arthritis (JIA) is very rare, only three cases with severe joint involvement and mortal ...

Objectives FMF is the most common autoinflammatory disease characterized by recurrent febrile polyserositis. The gravest consequence of FMF is nephropatic amyloidosis of AA type, which may progress to affect other organs, including the lungs[]. Pulmonary hypertension (PH) in FMF related amyloidosis is rare; only a few cases have been reported so far[,]. We aim to elucidate development of PH in ...

OBJECTIVE Trisomy 21 is associated with a flat face, which can now be quantified by measurement of the frontomaxillary facial (FMF) angle. The aim of this study was to examine whether in trisomy 21 fetuses fetal nuchal translucency (NT) thickness and maternal serum free ss-human chorionic gonadotropin (ss-hCG) and pregnancy-associated plasma protein-A (PAPP-A) are independent of the FMF angle, ...