The pharmacokinetics of fluorescein in the vitreous after intravenous or oral fluorescein administration was studied in normal individuals. Vitreous and free blood fluorescein concentrations were measured over an 8 hr period by fluorophotometry and fluorescence polarization. A computer model was constructed based on the free plasma fluorescein concentrations and conformed closely to the experim...

Aims: To assess the ocular bioavailability of fluorescein from a novel water free, freeze dried ophthalmic drug delivery system compared to conventional preservativefree fluorescein eye drops. Methods: Sodium fluorescein 0.17% was dissolved in an aqueous solution of hydroxypropylmethyl cellulose 1.0% (HPMC), deposited on sterilised flexible hydrophobic poly(tetrafluoroethylene) (PTFE) carrier s...

Fluorescein-bovine albumin conjugates have been prepared and found not to differ appreciably in size, shape, and homogeneity from the precursor, bovine serum albumin. Fluorescein has also been conjugated to rat plasma proteins. Their disappearance rates from the circulation of rats correspond with those obtained from the use of isotope labeling. Their sites of localization in rat tissues were s...

Objective: The ability of bacteria to develop resistance existing antibiotics has made the search for new antimicrobials or antimicrobial formulations a matter urgency. Among drug delivery systems, solid lipid nanoparticles are considered solution-oriented systems with advantages targeted delivery. Material and Method: In this study, bacterial uptake SLNs encapsulated fluorescein into Staphyloc...