OBJECTIVES It is well known that familial hypercholesterolemia (FH) is a common inherited disorder that can markedly elevate the level of plasma LDL cholesterol. However, little data exists regarding the clinical impact of the plasma triglyceride (TG)-rich lipoprotein fraction, including VLDL and IDL, in FH. Thus, we assessed the hypothesis that the mutations in the LDL receptor modulate lipopr...

Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in LDL receptor gene. The penetrance of FH is almost 100%, meaning that half of the offspring of affected parents born with disease. The patients are at risk of premature coronary heart disease (CHD). There is no report about the molecular basis of FH in Iran. Identification of mutat...

In this paper, a thermal model is developed for the bus bar system to predict the temperature variation during the transient time period and to calculate both the steady-state and transient electrical current carrying capacity (ampacity) of bus bar. The bus bar system installed in the power house of Kumaraguru College of Technology, Coimbatore has been considered. Temperature variation predicte...

BACKGROUND AND PURPOSE Thickening of the LF is ascribed to buckling due to DSN. Uncertainty exists as to whether this can occur without DSN. Our primary hypothesis was that facet degenerative changes alone, independent of DSN, can thicken the LF. Our secondary hypothesis was that inflammatory changes surrounding degenerative facet joints may incite thickening. MATERIALS AND METHODS Fifty-two ...

familial hypercholesterolemia (fh) is an inherited common autosomal mendelian disorder of lipoprotein metabolism with a population prevalence of 1 in 500. fh is characterized by severely elevated levels of low-density lipoprotein cholesterol (ldl-c), which result in surplus deposition of cholesterol in tissues. this condition leads to premature at hero sclerosis and early-onset of coronary hear...

Objectives: The objective of the study is to determine relationships between ramus height and occlusal planes (OPs) in Han Chinese individuals with normal occlusion. Materials Methods: Two hundred four participants occlusion were included their cephalograms analyzed. (Ar-Go), Frankfort horizontal plane-posterior OP (FH-POP), FH-anterior (FH-AOP) FH-OP, anterior posterior cranial base length, SN...

McCommis KS, McGee AM, Laughlin MH, Bowles DK, Baines CP. Hypercholesterolemia increases mitochondrial oxidative stress and enhances the MPT response in the porcine myocardium: beneficial effects of chronic exercise. Am J Physiol Regul Integr Comp Physiol 301: R1250–R1258, 2011. First published August 24, 2011; doi:10.1152/ajpregu.00841.2010.—Hypercholesterolemia has been suggested to have dire...

Prediction of immunogenicity is a substantial barrier in vaccine design. Here, a molecular dynamics approach to assessing the immunogenicity of nanoparticles based on structure is presented. Molecular properties of epitopes on nonenveloped viral particles are quantified via a set of metrics. One such metric, epitope fluctuation (and implied flexibility), is shown to be inversely correlated with...