BACKGROUND Reporting of the flow of participants through each stage of a randomized trial is essential to assess the generalisability and validity of its results. We assessed the type and completeness of information reported in CONSORT (Consolidated Standards of Reporting Trials) flow diagrams published in current reports of randomized trials. METHODS A cross sectional review of all primary r...

Software testing involves identifying the test cases which discover errors in the program. However, exhaustive testing of software is very time consuming. In this paper, a technique is proposed to prioritize test case scenarios by identifying the critical path clusters using genetic algorithm. The test case scenarios are derived from the UML activity diagram and state chart diagram. The testing...

Separation of a racemic mixture of ibuprofen at a low concentration level by supercritical fluid chromatography in a simulated moving bed (SFC-SMB) is investigated by simulation. The feasibility of ibuprofen enantiomers separation has been experimentally examined in the literature. Our simulation results show that separation of ibuprofen enantiomers is feasible by this method, and R-ibuprofen a...

Most distributed real-time embedded systems are specified combining state diagram and data flow languages. This leads to several real-time codes which together do not necessarily satisfy the global specification, and consequently increases the development cycle because more tests are needed. Then, we propose, in order to obtain a single real-time code, to translate state diagram specification i...

This paper proposes new analysis method, called POAM (Problem-Oriented Analysis Method). POAM has been developed to solve several shortcomings of existing conceptual models (solution orientation and dependence of concrete development approaches). Those shortcomings have adverse effects on software development, since practitioners are encouraged to think in terms of a solution before the problem...

This paper proposes new analysis method, called POAM (Problem-Oriented Analysis Method). POAM has been developed to solve several shortcomings of existing conceptual models (solution orientation and dependence of concrete development approaches). POAM uses a kind of conceptual model unbiased towards any development approach, thus supporting developers to understand the problem and its constrain...

The motion of red blood cells (RBCs) in microcirculation plays an important role in blood flow resistance and in the cell partitioning within a microvascular network. Different shapes and dynamics of RBCs in microvessels have been previously observed experimentally including the parachute and slipper shapes. We employ mesoscale hydrodynamic simulations to predict the phase diagram of shapes and...