After traumatic injury to the spinal cord, the neural tissue degenerates, resulting in lost function below the site of injury. Promoting axonal regeneration after injury remains a challenge; however, guidance channels have demonstrated some success when combined with cellular and protein therapies. One of the limitations of current guidance channels is the inability to deliver therapeutically r...

PURPOSE The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release mod...

The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than juice and remain on for a long period of time without impacting the gastric-emptying rate increasing bioavailability. Gastro-retentive microspheres particularly suitable continuous or late release oral formulations with blending versatility achieve various pat...

The objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; Eudragit RL 100 (Eu RL) and cellulose acetate butyrate (CAB) using the oil-in-oil emulsion solvent evaporation method. Polymers were used separately and in combination to prepare different microcapsules. The effect of d...

Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to specific region. free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging 1 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption desorption by regeneration .The...

BACKGROUND AND THE PURPOSE OF THE STUDY Lovastatin is an antihyperlipidemic agent which has low bioavailability due to the extensive first pass metabolism. It was sought to increase gastric retention of lovastatin by development of a sustained release gastroretentive drug delivery system leading to reduced fluctuation in the plasma concentration and improved bioavailability. MEHODS: Floating m...

The purpose of the present investigation was to develop a gastro-retentive cilnidipine loaded floating microspheres. microspheres were prepared by solvent evaporation method for oral drug delivery using HPMCK4M and ethyl cellulose as polymers. evaluated particle size, content, entrapment efficiency time. in-vitro study performed in pH 1.2 determine amount released. Field emission scanning elect...

Microspheres are multiparticulate drug delivery systems that designed to deliver drugs a particular location at fixed rate. free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 1000µm. Benefits the use microspheres in fields such as delivery, bone tissue manufacturing, and absorption desorption contaminants by regeneration. The study sh...

In order to increase bioavailability, stability, and target the drug a specific region at predetermined rate, floating microspheres, multi-unit delivery systems, are designed accomplish controlled or delayed administration. clinical practise, drugs that have an upper small intestine absorption window may benefit most from system with extended stomach residence period. The non-uniformity of medi...