The purpose of this study was to investigate flexible nanoliposomes for mediating topical delivery of daptomycin, and to document permeation rates and bacteriostatic activity towards skin infections. Response surface methodology was used to optimize the daptomycin-loaded flexible nanoliposomes (DAP-FL), and the amount of drug loaded into the particles was evaluated as the investigation index. T...

background: water fl uoride level is unknown in many regions of iran. besides, only few noncontrolled studies world-wide have assessed the effect of water fl uoride on dental fl uorosis and caries. we aimed to measure the fl uoride level of 76 water supplies in 54 cities and evaluate the effect of fl uoride on dental caries and fl uorosis in a large multi-project study. materials and methods: i...

Background: To determine whether a child has asthma exacerbation, we should obtain the value of peak expiratory fl ow. It is useful in a diagnostic procedure, in evaluation of response to therapy and following the course of asthma. The context and purpose of the study: On the basis of published relations between body height and peak expiratory fl ow in children I developed a formula for calcula...

A 52-year-old woman develops right neck lymphadenopathy in the absence of systemic symptoms. Excisional biopsy specimen shows grade 1-2 follicular lymphoma (FL). Physical examination reveals a cluster of 1to 2-cm right cervical nodes but no other abnormalities. Lactate dehydrogenase is 400 U/L (normal: 140-210 U/L), b-2 microglobulin is 4.1 mg/mL (normal: 0-2.5 mg/mL), and a complete blood coun...

Sweeping is an effective and convenient way for online sample preconcentration in micellar electrokinetic chromatography. The usual procedure includes a hydrodynamic injection step carried out by applying pressure to the sample vial followed by the subsequent sweeping and separation processes. The injected sample volume is limited by the dimensions of the capillary because a part of the capilla...

AIM To evaluate the clinicopathological features and the surgical outcomes of patients with fibrolamellar hepatocellular carcinoma (FL-HCC) over a 15-year period. METHODS This is a retrospective study including 22 patients with a pathologic diagnosis of FL-HCC who underwent hepatectomy over a 15-year period. Tumor characteristics, survival and recurrence were evaluated. RESULTS There were 1...

This study aimed to understand the size-specific spatiotemporal dynamics of bigeye tuna (Thunnus obesus) in eastern Pacific Ocean from 1991 2017. A delta-generalized linear mixed model was applied catch rate data by size class collected a Japanese longline fishery. The results showed that density varied spatially across Ocean, with spatial segregation size. mean predicted area (100–150 °W, 10 °S–...

BACKGROUND The risk of developing injuries during standing work may vary between persons with different foot types. High arched and low arched feet, as well as rigid and flexible feet, are considered to have different injury profiles, while those with normal arches may sustain fewer injuries. However, the cut-off values for maximum values (subtalar position during weight-bearing) and range of m...

Carbon nanoparticles (CNPs) are grown on fl exible carbon fabric via a simple and low-cost fl ame synthesis process. The entire struture of the carbon fabric substrate retains its high fl exibility after the growth of CNPs and can even be rolled-up and twisted to a large degree without affecting the electric characteristics. No appreciable changes in the conductance can be observed under differ...

The demographics of the southern bluefin tuna (SBT) Thunnus maccoyii spawning stock were examined through a large-scale monitoring program of the Indonesian longline catch on the spawning ground between 1995 and 2012. The size and age structure of the spawning population has undergone significant changes since monitoring began. There has been a reduction in the relative abundance of larger/olde...