BACKGROUND The indications for a cochlear implant (CI) have been extended to include patients with some residual hearing. Shorter and thinner atraumatic electrodes have been designed to preserve the residual hearing in the implanted ear. However, the insertion of the electrode array into the cochlea, with potential mechanical trauma and the presence of this foreign body inside the cochlea, may ...

OBJECTIVE To investigate (a) the applicability of the proportional recovery rule of spontaneous neurobiological recovery to motor function of the paretic lower extremity (LE); and (b) the presence of fitters and non-fitters of this prognostic rule poststroke. When present, the clinical threshold for fitting nor non-fitting would be determined, as well as within-subject generalizability to the p...

Simulations based on disease-progression models and phase II trial results can predict phase III results and have the potential to improve oncology drug development by informing end-of-phase II decisions (EOP2Ds). Many barriers impede effective use of modeling and simulation (M&S) for EOP2Ds in oncology: concerns about model validity, lack of access to M&S results and patient-level data, limite...

AIM To describe initial lens selection and our experience of Rose K lens fitting in keratoconus in Indian eyes. METHODS Retrospective study of patients who underwent the Rose K contact lens (CL) trial during a 6-month period from July 2007 to December 2007 in a tertiary eye care centre in South India. We obtained data on patient demographics, prefitting refraction and best spectacle-corrected...

In this paper we investigate the within-subject variability of dynamical aspects of the BOLD response obtained in a series of fMRI sessions several days apart. Five different parameters describing the temporal behavior of trial-averaged time courses, such as time-to-peak and time-to-onset, were estimated and analyzed with respect to their variability across nine sessions. Results show that smal...

conclusions project management may benefit both the managerial and scientific aspects of medical projects and reduce fund waste. however, little has been written to date on project management in the context of clinical research. the suggestions represent the views of the individual authors. to provide a high level of evidence in this regard, we recommend that a randomized controlled trial be pe...

This research is collaborative investigation with the general-purpose motor manufacturer. To review construction method in production process, we applied the parameter design method of quality engineering and tried to approach the optimization of construction method. Conventionally, press-fitting method has been adopted in process of fitting rotor core and shaft which is main component of motor...

BACKGROUND Despite evidence suggesting inaccuracy in the default fittings provided by hearing aid manufacturers, the use of probe-microphone measures for the verification of fitting accuracy is routinely used by fewer than half of practicing audiologists. PURPOSE The present study examined whether self-perception of hearing aid benefit, as measured through the Abbreviated Profile of Hearing A...

This paper presents an ‘adaptive probability of crossover’ technique, as a variation of the differential evolution algorithm (ACDE), for optimal parameter estimation in the general curve-fitting problem. The technique is applied to the determination of orbital elements of a spectroscopic binary system (eta Bootis). In the ACDE, Varying the crossover probability rate (Cr) provides faster converg...