In acute myeloid leukemia (AML), clonal chromosomal aberrations constitute markers of diagnostic value and the molecular characterization of numerous abnormalities has greatly improved the understanding of the biology of distinct subtypes of the disease. Two of the most common recurring chromosomal abnormalities in AML are t(8;21) and inversion of chromosome 16 or its variant which belong to co...

Fish constitute a paraphyletic and profusely diversified group that has historically puzzled ichthyologists. Hard efforts are necessary to better understand this group, due to its extensive diversity. New species are often identified and it leads to questions about their phylogenetic aspects. Cytogenetics is becoming an important biodiversity-detection tool also used to measure biodiversity evo...

Since the very beginning Cytogenetics, the science of chromosomes and chromosome complements (Sutton, 1903) originally represented the microscopic level of genetic knowledge. Chromosomes (term coined by Waldeyer, 1888) were observed during mitotic and meiotic divisions already in the second half of the 19th century. In the early days of chromosome research, when the chemical nature of chromosom...

Fluorescence in situ hybridization (FISH), which allows direct mapping of DNA sequences on chromosomes, has become the most important technique in plant molecular cytogenetics research. Repetitive DNA sequence can generate unique FISH patterns on individual chromosomes for karyotyping and phylogenetic analysis. FISH on meiotic pachytene chromosomes coupled with digital imaging systems has becom...

Fluorescence in situ hybridization (FISH), which allows direct mapping of DNA sequences on chromosomes, has become the most important technique in plant molecular cytogenetics research. Repetitive DNA sequence can generate unique FISH patterns on individual chromosomes for karyotyping and phylogenetic analysis. FISH on meiotic pachytene chromosomes coupled with digital imaging systems has becom...

Assiduous surveillance for genetic aberrations is necessary in patients on cytotoxic therapies to detect therapy-related myeloid neoplasms (t-MN). Current modalities include metaphase cytogenetics and FISH. Since t-MN may develop abruptly in cytogenetically normal patients, a discussion exploring additional methods such as SNP-array and targeted-deep-sequencing to detect subchromosomal abnormal...

The field of human cytogenetics has been through many different stages of development, each of them improving the characterisation of structurally abnormal and/or supernumerary chromosomes. The era of reliable identification of human chromosomes started with the invention of the banding method by Dr Lore Zech in 1968. The introduction of fluorescence in situ hybridisation (FISH) techniques in h...

The field of human cytogenetics has been through many different stages of development, each of them improving the characterisation of structurally abnormal and/or supernumerary chromosomes. The era of reliable identification of human chromosomes started with the invention of the banding method by Dr Lore Zech in 1968. The introduction of fluorescence in situ hybridisation (FISH) techniques in h...