zinc is one of the most important micronutrient with essential role in biochemical regulation of the body functions. the importance of zinc in pregnancy period was widely studied in various countries. variation in zinc plasma levels during pregnancy needs more investigation, because maternal zinc deficiencies may cause some severe abnormalities in the fetus. in this study the plasma levels of z...

Two studies suggest an increased risk of miscarriage after nonsteroidal anti-inflammatory drugs (NSAID) use during the first trimester of pregnancy. The NSAID exposure during the first trimester of pregnancy could also be related to an increased risk in congenital anomalies (specifically cardiac defects). However, this teratogenic potential remains uncertain. In practice, a benefit/risk evaluat...

PURPOSE To study systemic and retinal circulatory variables and vasoactive hormones during pregnancy in women with and without diabetes. METHODS Prospective study of 45 women with type 1 diabetes and 6 healthy pregnant women, from the first trimester of pregnancy to half a year after delivery, by using a fundus photographic method of determining retinal vessel diameters. RESULTS In diabetic...

It seems appropriate to use propylthiouracil to treat maternal hyperthyroidism during the first trimester of pregnancy. We present the case of a 26-year-old woman with acute liver failure associated with propylthiouracil during the first trimester of pregnancy. She was successfully treated without liver transplantation. Attention should be paid to the possible occurrence of propylthiouracil-ind...

It is still unclear to which extent methyl-group intake during pregnancy can affect maternal global DNA (hydroxyl)methylation. Pregnancy methylation profiling and its link with methyl-group intake in a healthy population could enhance our understanding of the development of pregnancy related disorders. One hundred forty-eight women were enrolled in the MANOE (MAternal Nutrition and Offspring's ...

BACKGROUND Since 1998, Italian law requires serological screening for toxoplasmosis by the thirteenth week of pregnancy, and seronegative women should undergo further checks every 30 - 40 days until delivery (a total of 5 - 7 screenings). This is an improvement of the previous law which foresaw three free tests (one by the end of the third month, one in the fifth, and one in the ninth month of ...

OBJECTIVE To review the clinical indications for first trimester ultrasound. OUTCOME Proven clinical benefit from first trimester ultrasound. EVIDENCE MEDLINE search and bibliography reviews in relevant literature. VALUES Content and recommendations reviewed by the principal authors and the Diagnostic Imaging Committee of the Society of Obstetricians and Gynaecologists of Canada. Levels o...

INTRODUCTION Performing a myomectomy during pregnancy is extremely rare due to the risk of pregnancy loss, hemorrhage and hysterectomy. Favorable outcomes have been demonstrated with select second trimester gravid myomectomies. Literature documenting first trimester surgical management of myomas during pregnancy is scant. Patients with symptomatic myomas failing conservative management in the f...

We determined plasma human atrial natriuretic peptide (hANP) levels in normal pregnancy and pregnancy induced hypertension (PIH). The plasma hANP levels slightly decreased in the first trimester of normal pregnancy and tended to recover as pregnancy advanced, although these changes were slight. However, the plasma hANP level in puerperium was higher than that in the third trimester of normal pr...