Simulink models are created to represent the control application as well as the plant being controlled. These models may represent a single control application, e.g., an electronic throttle control, or a collection of control applications that may interact with each other, e.g., cruise control and braking system. Each control application and controlled plant element may be modeled in more than ...

This paper presents a prototyping framework situated mid-way between low fidelity and high fidelity. The framework is used after requirements definition and early design but before development. The approach provides a solution to the classical trade-off between the ease of production associated with low-fidelity approaches and the realism associated with high-fidelity techniques. Within this fr...

This paper presents a provably convergent multifidelity optimization algorithm for unconstrained problems that does not require high-fidelity gradients. The method uses a radial basis function interpolation to capture the error between a high-fidelity function and a low-fidelity function. The error interpolation is added to the low-fidelity function to create a surrogate model of the high-fidel...

1. Abstract 2. Importance of retroviral genetic variation 3. Historic developments in understanding retroviral genetic variation and RT fidelity 4. Factors that influence retroviral mutation rates 4.1. Reverse transcription 4.2. Other viral proteins 4.3. Nucleotide pools, DNA repair, and mammalian DNA polymerases 4.4. RNA transcription 4.5. RNA modification 4.6. Antiviral nucleoside analogs 5. ...