BACKGROUND Flow-induced regulation of endothelial NO synthase (eNOS) depends on integrin signaling and tyrosine kinase activation. Integrins cluster in focal adhesion complexes, where the extracellular matrix is connected to the cytoskeleton and where focal adhesion kinase (FAK) is located. FAK plays a central role in integrin signaling and Src activation. Accordingly, we hypothesized that FAK ...

Introduction Pass-band bSSFP is a promising tool for high-resolution fMRI, but its signal sources have been unclear especially at high field. The bSSFP signals are summation of free induction decay (FID) component and echo components from multiple RF pathways. Multiple TR and TE experiments have been used in previous studies to understand contributions of FID and echo components to the signals ...

BACKGROUND Fever of intermediate duration (FID), characterized by a febrile syndrome lasting from 7 to 28 days, is a frequent condition in clinical practice, but its epidemiological and etiologic features are not well described. Murine typhus (MT) is a worldwide illness; nevertheless, to our knowledge, no studies describing its epidemiological and clinical characteristics have been performed in...

We studied the roles of estrogen receptors (ER) and aromatase in the mediation of flow-induced dilation (FID) in isolated arteries of male ERalpha-knockout (ERalpha-KO) and wild-type (WT) mice. FID was comparable between gracilis arteries of WT and ERalpha-KO mice. In WT arteries, inhibition of NO and prostaglandins eliminated FID. In ERalpha-KO arteries, N(omega)-nitro-L-arginine methyl ester ...

Our previous studies demonstrated that, in gracilis muscle arterioles of male mice deficient in the gene for endothelial nitric oxide synthase (eNOS), flow-induced dilation (FID) is mediated by endothelial PGs. Thus the present study aimed to identify the specific isoform of cyclooxygenase (COX) responsible for the compensatory mediation of FID in arterioles of eNOS-knockout (KO) mice. Experime...

this essay examines the practice of free indirect discourse (fid), as a narrative-stylistic device, in hossein sanapour’s lips on a blade (2010). after a brief overview of the novel ’s narrative structure, the four modes of representing characters’ discourses in narrative fiction are introduced and exemplified. among these modes, fid is the most important since it is the only one which leads to...

Introduction: MR spectroscopy can be used to identify various metabolites and their quantities in vivo and provide biochemical information that can be correlated with disease. For example, MR spectroscopy of the brain can show levels of creatinine (Cr), choline (Cho), and N-acetyl aspartate (NAA), which are correlated with the presence or absence of tumor. One of the major drawbacks in MR spect...

this paper examines translating free indirect discourse (fid) in three persian translations of woolf's to the lighthouse. first, it is referred to narrative discourse and the linguistic markers of fid as well as its effects and functions briefly. then, translating fid in three hoseini's, bejanian's and keyhan's translations of woolf's novel is analyzed, through comparin...

In North America and Europe, deer (Cervidae)–vehicle collisions (DVCs) are common and result not only in injury and death to the animals involved, but also human injury and property damage. Given that most DVCs occur during crepuscular periods, we questioned whether the perceived threat to deer posed by vehicle approach could be enhanced. We hypothesized that a vehicle-based lighting system tha...

We present FiD (Fragment iDentificator), a software tool for the structural identification of product ions produced with tandem mass spectrometric measurement of low molecular weight organic compounds. Tandem mass spectrometry (MS/MS) has proven to be an indispensable tool in modern, cell-wide metabolomics and fluxomics studies. In such studies, the structural information of the MS(n) product i...