Keloids represent a common form of exaggerated cutaneous scarring that is difficult to prevent or treat effectively. TGF-β has been implicated in driving abnormal wound healing responses and generating excessive extracellular matrix (ECM) deposition but the pathobiology keloids remains poorly understood. Here, we show mRNA protein levels tumor endothelial marker 1 (TEM1/endosialin/CD248), glyco...

Abstract Background/Aims The intracellular chloride ion channel CLIC4 mediates the activation of cancer associated fibroblasts. Interestingly, systemic sclerosis (SSc) fibroblasts display a number similar properties to Tissue fibrosis in SSc is driven by active (myofibroblasts). Therefore this study we investigated role fibroblast activation. Methods Dermal were obtained from full thickness ski...