In an earlier paper, Reed, Orr and Smith (1941), demonstrated that the more actively pathogenic species of gas-gangrene anaerobes produce fibrinolysis when tested by the familiar procedure of Tillet and Garner (1933). Carlsen (1939) has previously shown that Clostridium histolyticum produces an active fibrinolysin. The eleven species of the genus Clostridium (some seventy-seven strains) tested ...

THE magnlitude of the literature dealing with deep thrombophlebitis of the lower extremities and its complications reflects not onily the interest that this disorder commands among physicians but also the extensive controversy that it has generated. Controversy surrounds even such fundamental problems as the pathogenesis of venous thromboembolism, the natural course of the process, and the adeq...

Two cases of ha-mophilus influenzameningitis have been described who showed lack of response to the routine antibiotics. These two cases did not respond to the oral Penbritin because of vomiting and were treated with intramuscular and intrathecal Penbritin with successful results as shown by biochemical and clinical responses. It should be stressed that neither of these preparations of Penbriti...

Plasminogen (profibrinolysin) of high specific activity has been prepared from human sources and converted to plasmin (fibrinolysin) by a variety of means (3, 4). Since these preparations seemed to possess activities of as high an order as any that had yet been produced, it was considered appropriate to examine their purity by physicochemical means. Such investigations do not appear to have bee...

Staphylococcus aureus Cowan I was exposed to nitrosoguanidine or ethyl-methanesulfonate, and survivors were screened on nutrient agar plates containing rabbit anti-protein A serum for loss of protein A production. More than half of all protein A-deficient mutants also lacked nuclease, coagulase, alpha hemolysin, fibrinolysin, mannitol utilization, and the phage-type pattern. Mutants with a spec...

Background and objectives: The wounds are still the health tribulations at the present time. In the present research the effect of a new herbal ointment (Oppyheal) in treatment of rat’s wound has been investigated. The effectiveness of the ointment was compared with the Fibrinolysin/DNAse. Methods: Fifty four male Wistar rats were used. The wound was crea...

A strain of pathogenic Staphylococcus aureus, grown under special conditions, accumulates extracellular metabolites about the bacterial cells. This phenomenon may simulate, but is differentiable from, the capsulation of, for instance, the mucoid "Smith" strain. The special nutrient requirements, namely lactose, mannitol, vitamin, and gelatin containing medium, promote the production and accumul...

Certain strains of Moraxella bovis produce tissue-damaging enzymes which may initiate or potentiate infectious bovine keratoconjunctivitis. Thirteen reference strains of this species were characterized physiologically and screened for production of various enzymes by some conventional biochemical tests and the API ZYM system (Analytab Products, Plainview, N.Y.). All 13 strains were hemolytic. A...