A new, autosomally inherited abnormal fibrinogen associated with hypofibrinogenemia has been described in several members of a family. Plasma fibrinogen measured either as thrombin-clottable protein or by immunodiffusion revealed a fibrinogen level ranging between 60 and 90 mg/100 ml. The thrombin time of plasma or purified fibrinogen was prolonged and only partially corrected by the addition o...

BACKGROUND We aimed to create a theoretical tool to model the effect of three haemostatic agents containing fibrinogen (therapeutic plasma, cryoprecipitate, and fibrinogen concentrate) on the patient's plasma fibrinogen level. METHODS A mathematical model was developed step-wise. The relationship between the amount of haemostatic agent and plasma fibrinogen level was plotted for each agent. A...

Previous studies indicated a correlation between the formation of EDTA-resistant (irreversible) platelet-fibrinogen interactions and platelet cytoskeleton formation. The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated ...

Pathological erythrocyte aggregation reduces capillary perfusion and oxygen transfer to tissue, which is determined by the negative surface charge on membrane (intrinsic aggregability) fibrinogen–erythrocyte interaction (extrinsic factor). Exercise-induced oxidative stress important for rheological adaptation training but may also cause senescence. This study clarifies effects of hypoxic exerci...

the purpose of this research was to determine the effects of intermittent and continuous training on inflammatory factors of crp and fibrinogen of young obese females. for this purpose, 36 obese sedentary subjects (body mass index>30) were randomly selected and randomly assigned to 3 groups of 12 subjects :intermittent training, continuous training and control (mean and sd of height, weight, ag...

Neurodegenerative diseases are prevalent and currently incurable conditions that progressively impair cognitive, behavioral, psychiatric functions of the central or peripheral nervous system. Fibrinogen, a macromolecular glycoprotein, plays crucial role in inflammatory response tissue repair human body interacts with various system cells due to its unique molecular structure. Accumulating evide...

Granulosa cells from ovarian follicles were shown to express and secrete fibrinogen under the control of FSH. Conditioned medium was collected from granulosa cell cultures and found to contain FSH-dependent 50-kilodalton (kDa) and 93- to 95-kDa proteins. N-Terminal microsequence analysis identified these proteins as fibrinogen beta- and gamma-chains, respectively. Proteins migrating at 93 and 9...

Fibrinogen synthesis was investigated in guinea pig megakaryocytes. Purified megakaryocytes were incubated with 35S-methionine in methionine-free incubation medium for 18 hours. Newly synthesized fibrinogen in megakaryocyte lysates enriched with purified carrier guinea pig fibrinogen was immunoprecipitated with a specific anti-guinea pig fibrinogen antiserum produced in rabbits. Proteins in the...