BACKGROUND Axillary lymphadenectomy or sentinel biopsy is integral part of breast cancer treatment, yet seroma formation occurs in 15-85% of cases. Among methods employed to reduce seroma magnitude and duration, fibrin glue has been proposed in numerous studies with controversial results. METHODS Eighty patients underwent quadrantectomy or mastectomy with level I/II axillary lymphadenectomy; ...

BACKGROUND Individuals with impaired immunity are at higher risk of perianal diseases. Concerning complex anal fistulas impaired healing and complication rates are also higher. Definitive treatment of a fistula aims controlling the purulent discharge and prevents its recurrence. It depends mainly on the trajectory of the fistula and the underlying disease. We present a case of a HIV-positive pa...

For tissue engineering of bone, a carrier matrix and efficient cell seeding are desirable. This study analysed the effect of fibrin glue on bone marrow stromal cells (BMSC) adhesion, proliferation (MTS-Test), differentiation (alkaline phosphatase (AP), osteocalcin (OC), ELISA) and compared the results with cells seeded within culture media on a decellularized, xenogenic bone matrix. There was n...

OBJECTIVES/HYPOTHESIS Suture closure and fibrin glue placement have been advocated as alternatives to healing by secondary intention. The aim of this study was to examine the tensile strength of these microflap closure techniques. STUDY DESIGN Basic research. METHODS Three pairs of excised bovine true vocal folds underwent microflap creation and closure by either single 6-0 polyglactin sutu...

Lymphangiomas are congenital cystic tumors developing in the neck, axilla, chest and trunk. Characteristically they are composed of multiple sacs or loculation of lymphatic fluid. Cysts can vary in size from microcysts to large cystlike dilatations. The tumor can compress vital structure. The close relation of this benign tumor with vital structures reduces the chances of complete surgical exci...

Fibrin glue injection has been used to control intraoperative cavernous sinus (CS) venous bleeding. There have been no reported complications related to this maneuver. We present a case where a patient developed a sensory trigeminal nerve deficit after injection of fibrin glue into the posterior CS during resection of a petrosal meningioma. We believe that this deficit was due to the compressio...

Surgical repair of cerebrospinal fluid (CSF) leak requires the production of a seal competent to resist CSF pressure during the period of healing. Direct suturing, packing with muscle and fat grafts, and coverage with mucosal or muscle flaps have been effective in repairing most CSF leaks. Fibrin glue will improve the results of a CSF leak repair by providing better adhesion of the graft and im...

Iatrogenic preterm prelabor rupture of membranes (iPPROM) remains the main complication after invasive interventions into the intrauterine cavity. Here, the proteolytic stability of mussel-mimetic tissue adhesive (mussel glue) and its sealing behavior on punctured fetal membranes are evaluated. The proteolytic degradation of mussel glue and fibrin glue were compared in vitro. Critical pressures...

BACKGROUND The management of an enterocutaneous fistula poses a significant challenge to surgeons and is often associated with a costly hospital stay and long-term discomfort. The use of fibrin glue in the fistula tract has been shown to promote closure of low output enterocutaneous fistulas. Our previous nonrandomized study demonstrated that autologous platelet-rich fibrin glue treatment signi...

BACKGROUND In surgical and endoscopic procedures, tissue adhesives are commonly used as reinforcement of sutures or as bonding and hemostatic agents. Fibrin glues do not guarantee adequate properties for many clinical applications; on the contrary, cyanoacrylate glues guarantee high bonding strength between biologic tissues. The aim of this study was to provide evidence regarding adhesive and s...