A highly efficient catalyst system assembled from enantiomerically pure diaminocyclohexane and Ni(OAc)(2) is, for the first time, used to catalyze the cascade Michael-Henry reaction of various diones and substituted nitroalkenes. A series of polyfunctionalized bicyclo[3.2.1]octane derivatives containing four stereogenic centers are prepared with excellent enantioselectivities (up to >99% ee) an...

The asymmetric unit of the title co-crystal, C12H14N4O2S·0.5C6H12N2, comprises the sulfonamide mol-ecule and half a mol-ecule of 1,4-di-aza-bicyclo-[2.2.2]octane (DABCO), the latter being disposed about a crystallographic twofold rotation axis. In the sulfonamide mol-ecule, the aromatic rings are almost perpendicular to one another [dihedral angle = 75.01 (8)°]. In the crystal, mol-ecules are c...

In the crystal structure of the title cocrystal, 2C(24)H(18)ClNO(2)·C(6)H(12)N(2), the 1,4-diaza-bicyclo-[2.2.2]octane mol-ecule is located on a twofold rotation axis and linked to the two triaryl-imine mol-ecules by O-H⋯N hydrogen bonds, forming a 2:1 aggregate. C-H⋯Cl inter-actions are also observed. In the triaryl-imine mol-ecule, the naphthalene ring system makes dihedral angles of 80.39 (6...

An efficient and highly stereoselective total synthesis of the natural product (+/-)-welwitindolinone A isonitrile (1) is described. The bicyclo[4.2.0]octane core of 1 was established by a regio- and diastereoselective [2+2] ketene cycloaddition. The C12 quaternary center and vicinal stereogenic chlorine were installed in a single operation with excellent stereocontrol via a chloronium ion medi...

The effect of the phenyl-alkyl connecting group on mesogenic properties of several series of isostructural compounds containing p-carborane (A and B), bicyclo[2.2.2]octane (C), and benzene (D) was investigated using thermal and optical methods. Results demonstrated that mesophase stability in the series containing A-D follows the order (Alk)CH₂CH₂- < (Alk)OOC- < (Alk)CH₂O- < (Alk)COO-. Surprisi...

The influence of the geometry factor κ on efficiency energy transfer by FRET (Förster resonance transfer) was studied means dyads benzoperylene and perylene interlinked a spacer cage bicyclo-[2.2.2]octane. electronic transition moments were arranged orthogonally for extinguishing according to Förster's theory. In contrast theory proceeded unrestrictedly attributed molecular vibrations. A furthe...

In the title compound, phenyl (S)-2-[(S)-(1-{2-[(S)-(1-{[(tert-but-oxy)carbon-yl]amino}-bicyclo-[2.2.2]octan-2-yl)formamido]-propanamido}-bicyclo-[2.2.2]octan-2-yl)formamido]-3-phenyl-propano-ate chloro-form monosolvate, C42H56N4O7·CHCl3, the α,β-hybrid peptide contains two non-proteinogenic amino acid residues of (S)-1-amino-bicyclo-[2.2.2]octane-2-carb-oxy-lic acid [(S)-ABOC], two amino acid ...