abstract objective cardiac dysfunction is a major cause of death in patients with beta thalassemia. in these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. left ventricular ejection fraction was measured in major beta thalassemia (β-th) patients to detect the relati...

Background: Atrial fibrillation (AF) is the most common arrhythmia in patients with β-thalassemia major (β-TM) due to cardiac iron overload. AF may be predicted by changes in P wave parameters. The aim of this study was to evaluate the correlation between P-wave parameters and atrial markers with mean serum ferritin levels measured yearly. Methods: Fifty patients with β-TM and 50 healthy subje...

Effect of SI level and saturation of TIBC on the induction of ferritin in erythroid cells was investigated in rats, guinea pigs, and rabbits. Evidence presented indicates that species difference and serum iron level are important factors in induction of micropinocytotic ferritin in developing erythroid cells: (1) Micropinocytotic ferritin was occasionally seen in erythroblasts of control guinea...

We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial sta...

BACKGROUND Hemorrhagic Transformation (HT) of Ischemic Stroke (IS) is a detrimental complication. This study investigated the association between serum ferritin level and HT in patients with massive IS of middle cerebral artery. METHODS Thirty patients with massive IS of middle cerebral artery were enrolled in this prospective cohort study. They were divided into two groups based on the serum...

BACKGROUND The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A co...