Both circulating red blood cells and the liver store iron in ferritin during larval (bullfrog) or embryonic (mouse) development. In contrast, circulating red cells in adults do not store iron and the liver is the main site of iron storage and ferritin. The structure of larval red cell and liver ferritin was compared to adult liver ferritin and the redistribution of iron was measured during amph...

Ferritin is a large multisubunit protein that stores iron in plants, animals, and bacteria. In animals, the protein is mainly cytoplasmic and is highly conserved, while in plants ferritin is found in chloroplasts and other plastids. Ferritin is synthesized in plants as a larger precursor of the mature subunit. There is no sequence information for ferritin from plants, except an NH2-terminal pep...

aims: anemia occurs for different reasons. however the iron deficiency anemia (ida) is one of the most prevalent causes of anemia in all human communities. the goal of the present study was to assess the effect of serum ferritin deficiency on anemia in medical students. materials & methods: this cross-sectional study was conducted on students of kashan university of medical sciences in all educ...

Background and aims: Iron is stored in hepatocytes in the form of ferritin and haemosiderin. There is a marked increase in iron rich haemosiderin in iron overloaded livers, and ferric iron in amounts exceeding the ferritin and haemosiderin binding capacity may promote free radical generation, causing cellular damage. The aim of this study was to characterise hepatic haemosiderin using four anti...

Elevated serum ferritin levels without a corresponding increase in tissue iron storage have been observed in patients with certain cancers. Increased synthesis of ferritin by cancer cells has also been reported. In order to see whether similar phenomena occurred in patients with neuroblastoma, we have screened serum ferritin levels in 58 children with neuroblastoma by counterelectrophoresis usi...

We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial sta...

Iron is required for normal cell growth and proliferation. However, excess iron is potentially harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton chemistry. For this reason, cells have evolved highly regulated mechanisms for controlling intracellular iron levels. Chief among these is the sequestration of iron in ferritin. Ferritin is a 24 subunit protein...

BACKGROUND AND AIMS Iron is stored in hepatocytes in the form of ferritin and haemosiderin. There is a marked increase in iron rich haemosiderin in iron overloaded livers, and ferric iron in amounts exceeding the ferritin and haemosiderin binding capacity may promote free radical generation, causing cellular damage. The aim of this study was to characterise hepatic haemosiderin using four antib...

Ocular tissues from two enucleated and one trabeculectomized human eyes with siderosis bulbi were studied by electron microscopy. Ferritin particles were demonstrated in various cell types of the three eyes. Other types of iron were not identifiable. The ferritin particles were scattered throughout the cytoplasm, with a few particles in the nucleus and extracellular space. More ferritin particl...

Ferritin was isolated from six Morris hepatomas with growth rates ranging from 3 to 12 days doubling time and also from regenerating rat liver. The ferritins from all six tumors differed electrophoretically from normal rat liver ferritin. Five of them migrated identically, and antigenic studies on four confirmed the change in protein structure. In response to iron treatment of the host, more fe...