The present study is about potential variations of bioactive compounds from different commercial brands of fenugreek; in relation to multiple organic solvent systems, antioxidants and antimicrobial assays. Total phenolic contents, total flavonoid contents, individual phenolic acids, and DPPH assays were checked whereas phenolics analysis was performed by HPLC spectrophotometrically. Antimicrobi...

The present study aims to examine the protective effect of fenugreek and the underlying mechanism against the development of diabetic nephropathy (DN) in streptozotocin- (STZ-) induced diabetic rats. A rat model of diabetes was successfully established by direct injection of STZ and then the rats were administered an interventional treatment of fenugreek. Parameters of renal function, including...

Background: Hyperlipidemia is very common in especially with the Indian diet context. So efforts are done time to time to find out the hypolipidemic ingredients in Indian diet itself, so with the use of those ingredients can neutralize the hyperlipidimia caused by a lot of fats used for cooking in India Objective: To assess and compare the hypolipidemic effect of Garlic and fenugreek. Method:A ...

Fenugreek seed has been shown to affect the intestinal microbiota and immunological responses in animals. A feeding trial with male castrated piglets was performed over 28 d without or with the addition of 1·5 g fenugreek seeds/kg complete diet in ten and eleven piglets, weaned at 21 d. In the intestinal tract, pH, lactate and SCFA were measured as major bacterial metabolites. Immune cell pheno...

BACKGROUND Drugs used both in classical chemotherapy and the more recent targeted therapy do not have cancer cell specificity and, hence, cause severe systemic side effects. Tumors also develop resistance to such drugs due to heterogeneity of cell types and clonal selection. Several traditional dietary ingredients from plants, on the other hand, have been shown to act on multiple targets/pathwa...

Many traditional treatments have been recommended in the alterative system of medicine for the diabetes mellitus. Current research is now directed towards finding naturally occurring antidiabetic properties from plant origin. In Indian system of medicine Trigonella foenum graecum is an important medicinal plant and its leaves and seeds have been used in various ailments and as a health tonic. T...

Trigonella foenum-graecum (fenugreek) is an important medicinal plant, well known for its anti-inflammatory properties. However, the underlying cellular and molecular mechanisms of its action remain largely unknown. The apoptosis associated speck like protein containing a caspase recruitment domain (CARD) (ASC) is central to inflammatory and cell death pathways in innate and adaptive immunity. ...

BACKGROUND The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes. MATERIALS AND METHODS Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chlorid...

BACKGROUND Trigonella foenum-graecum (fenugreek) seeds are known to exhibit potent antioxidant, hypoglycemic, and nephroprotective activities, as well as serve as excellent membrane stabilizers especially because of their content of novel furostanolic saponins. Our previous studies exhibited the broad spectrum safety and efficacy of Fenfuro, a novel T. foenum-graecum seed extract enriched in fu...

The purpose of the study is to formulate and evaluate a new, cheap and effective natural mucoadhesive agent that can be used as an effective alternative for traditional mucoadhesive agent. The study procedure involved extraction of mucoadhesive agent from the Trigonellafoenumgraecum (fenugreek) seeds, solubility testing of the mucilage obtained, phytochemical testing, determination of swelling ...