The mu character (μ) is incorrectly typeset as a one-quarter character (1⁄4) throughout this article. The publisher apologizes for the errors. In the “Bacterial strains, plasmids and growth conditions” subsection of the “Materials and Methods” section, the last sentence of the first paragraph should read: When required, the medium was supplemented with kanamycin at final concentrations of 40 μg...

In this issue of Blood, Ciciliano et al demonstrate that thrombus formation in ferric chloride (FeCl3) thrombosis models relies on physiochemical, rather than biological, mechanisms.

Although intravital microscopy models of thrombosis in mice have contributed to dissect the mechanisms of thrombus formation and stability, they have not been well adapted to study long-term evolution of occlusive thrombi. Here, we assessed the suitability of the dorsal skinfold chamber (DSC) for the study of thrombolysis and testing of thrombolytic agents by intravital microscopy. We show that...

We have assessed, whether six agents, that either inhibit free radical formation or scavenge free radicals once they are produced, can reduce the incidence of reperfusion-induced arrhythmias, whether a free radical-generating system (FeCl3 X adenosine diphosphate) can increase the incidence of reperfusion-induced arrhythmias, and whether "anti-free radical" interventions can reduce reperfusion ...

The effects of two mineral and two organic acids, four organic solvents (methanol, ethanol, 2-propano and acetone) and three inorganic metal salts in combination with temperature regimes 0 and 22C on the yield and resolubility of potato tuber proteins were studied. Using acids, the yield of precipitated protein ranged from 22.3% (citric acid, 0C) to 54.5% (acetic acid, 22C) of total protein; ho...

Platelets play pivotal roles in both hemostasis and thrombosis. Although models of intravital platelet imaging are available for thrombosis studies in mice, few are available for rat studies. The present effort aimed to generate fluorescent platelets in rats and assess their dynamics in a rat model of arterial injury. We generated CD41-ZsGreen1 transgenic rats, in which green fluorescence prote...

High electron affinity (EA) molecules p-type dope low ionization energy (IE) polymers, resulting in an equilibrium doping level based on the energetic driving force (IE-EA), reorganization energy, and dopant concentration. Anion exchange (AED) is a process whereby anion exchanged with stable ion from electrolyte. We show that AED can be predicted using isotherm model. The of (FeCl3-) for bis(tr...

Arterial thrombosis and its related diseases are major healthcare problems worldwide. Blebbistatin is an inhibitor of myosin II, which plays an important role in thrombosis. The aim of our study is to explore the effect and potential mechanism of blebbistatin on arterial thrombosis. A ferric chloride (FeCl3) solution at a concentration of 5% was used to induce carotid artery thrombosis in mice....