Sertraline Hydrochlride, the selective serotonin reuptake inhibitor (SSRI) is widely used in treatment of depression. Though Sertraline Hydrochloride is well absorbed after oral dosing, there is a first pass metabolism leading to a reduced bioavailability of the drug (44%). Therefore, the present investigation is concerned with the development of Fast Dissolving Tablets of Sertraline Hydrochlor...

The Fast Dissolving Drug Delivery Systems was an advancement that came into existence in the early 1970’s and combat over the use of the tablets, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery Systems serves as a major benefit over the conventional dosage forms since the drug gets rapidly disintegrated & dissolves in the saliva without the use of ...

promethazine hydrochloride, a 5-ht3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. to overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of promethazine hydrochloride for sublingual administration. taste maskin...

The intention of present research is to formulate and develop the meclizine hydrochloride fast dissolving tablets using sublimation method to enhance the dissolution rate. In this study an attempt was made to fasten the drug release from the oral tablets by incorporating the superdisintegrants and camphor as sublimating agent. The prepared fast dissolving tablets were subjected to precompressio...

Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the form...

Aim: The aim of this study was to design fast dissolving tablets (FDT) the anti -psychiatric drug, Haloperidol in liquisolid forms as a way enhance its dissolution profile and anti-psychiatric effect.
 Methodology: Solubility studies various solvents surfactants were conducted. solvent with high solubilizing ability tween 20 (80%), selected absorbed into carrier then coating material added...