'Klemp P, Staberg B, Madsbad S, Kolcndorf K. Smoking reduces insulin absorption from subcutaneous tissue. Br MedJ' 1982;284:237. 2 Binder C. Absorption of injected insulin. Acta Pharmacol Toxicol (Copenh) 1969 ;27(suppl 2): 1-84. 3Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 1982;5...

The study is an investigation of the acceptance and utilisation of Sulphadoxine-Pyrimethamine (Fansidar), the drug of choice for Intermittent Preventive Treatment in pregnancy, and Insecticide-Treated Nets among pregnant women who access different health facilities in Oyo State, Nigeria. Pregnant women (582) attending government primary healthcare antenatal clinics and 50 attending faith clinic...

OBJECTIVE A pre-tested questionnaire-based, retrospective study to highlight the causative factors, mode of presentation, complications and outcome of patients with Stevens Johnson syndrome. SETTING Aga Khan University Hospital over a 10 year period. METHODS All case records with a diagnosis of Steven Johnson Syndrome in the period 1990 to 2000 were retrospectively reviewed. Data was retrie...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 65-year-old man presented with a 5-day history of fever. He took an antimalarial drug (Fansidar;sulfadoxine/ pyrimethamine) without being tested for malarial parasite. and corrected reticulocyte count, 20%. Peripheral blood smear (PBS) displayed numerous b...

BACKGROUND During pregnancy and labor, the immune response is physiologically impaired and women are more susceptible to infections. Since many drugs may have potentially adverse effects on the fetus and newborn, less aggressive treatment regimens should be considered in pregnant and lactating patients. The aim of our study was to present the management of toxoplasmic retinochoroiditis during p...

PROBLEM Introduction and evaluation of evidence based medicine (EBM) into routine hospital practice. STRATEGY FOR CHANGE Routine EBM meetings introduced in 1997. DESIGN Review of outcomes of meetings from 1997 to 2004, focusing on their effect on clinical practice. SETTING Referral centre for tropical and domestic infectious diseases. KEY MEASURE FOR IMPROVEMENT: Outcome of meetings, clas...

The artemisinin based combination therapy (ACT) of artemether and lumefantrine (Co-artem) has recently replaced chloroquine and fansidar as the first line treatment policy drug in Uganda. It is necessary to develop practical procedures to monitor the likely emergence and spread of artemisinin resistant P. falciparum strains. We have analyzed the genotypes of PfATP6 in parasites from 300 stored ...

Sulfadoxine is predominantly used in combination with pyrimethamine, commonly known as Fansidar, for the treatment of Plasmodium falciparum. This combination is usually less effective against Plasmodium vivax, probably due to the innate refractoriness of parasites to the sulfadoxine component. To investigate this mechanism of resistance by P. vivax to sulfadoxine, we cloned and sequenced the P....

BACKGROUND & OBJECTIVES The purpose of this study was to compare antimalarial activity of Artemisia turanica Krasch as Iranian flora with current antimalarial drugs against Plasmodium berghei in vivo in mice. METHODS Air-dried aerial parts of Iranian flora A. turanica were collected from Khorasan, northeastern Iran, extracted with Et2O/MeOH/Petrol and defatted. Toxicity of herbal extracts was...