The new inotropic agent pren lte 01 was admini te in a canine model of acute ischemic heart failure d int and in venously patients witn severe chronic heart failure. Experimental heart failure in anesthetized dogs was induced by two vessel coronary artery constriction and intravenous prenalterol (0.005-15 ug/kg/min) was compared to dobutamine (0.001-30 ug/kg/min) and saline. Significant dose-de...

The modeling of statistical size effect of concrete structures that fail at crack initiation is studied, with special attention to the interaction between the autocorrelation length and the size of the failure zone. The mechanical failure of concrete is modeled by a network of axial springs with degrading stiffness. The heterogeneity of concrete is idealized by spatial variation of the tensile ...

A new failure criterion was presented to predict the ultimate strength of shale under the triaxial and polyaxial state of stress. A database containing 93 datasets was obtained from the results of the uniaxial, triaxial, polyaxial compressive tests, an indirect tensile test was collected from reliable references, and this test was carried out on the shale samples taken from the southwestern oil...

An excavation damage zone (EDZ) can be defined as a rock zone where the rock properties and conditions have been changed due to the processes related to an excavation. This zone affects the behavior of rock mass surrounding the construction that reduces the stability and safety factor and increase probability of failure of the structure. This paper presents an approach to build a model for the ...

BACKGROUND Injury of the interosseous talocalcaneal ligament (ITCL) has been recognized as a cause of subtalar instability, though lack of an accepted clinical test has limited the ability of clinicians to reliably make the diagnosis. Clinical effects of ITCL failure remain unclear because of insufficient understanding of the role of the ligament. METHODS Load-displacement characteristics of ...