Introduction The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR). Materials and methods This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-toc...

A simple and novel approach was developed to obtain water-dispersible silicon quantum dots (Si-QDs) of low toxicity that were able to selectively label the endoplasmic reticulum (ER) in live cells. A block copolymer (Pluronic F127) was used to coat the surface of Si-QDs. Si-QDs form aggregates with diameters of 20-40 nm and show an outstanding optical stability upon UV irradiation. Our F127-tre...

Propylamino-functionalized mesoporous thin films were synthesized via co-condensation of the oxide precursor tetraethoxysilane (TEOS, Merck) and the amine precursor 3-aminopropyltriethoxysilane (APTES, Fluka 98%) in the presence of the template (F127 block copolymer, Aldrich, Mw ~13600). The precursor solution was prepared using 0.8 TEOS:0.2 APTES:0.005 F127:24 EtOH:5.2 H2O:0.28 HCl. This solut...

Nitrogen-containing ordered mesoporous carbon (NOMC) was synthesized by using m-aminophenol (MAP) as a carbon and nitrogen co-precursor via a co-assembly process with F127 in aqueous phase and exhibited a good catalytic performance for selective oxidation of ethylbenzene.

The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) ...

Aqueous single-walled carbon nanotube dispersions are often made using polymers from the pluronic family of amphiphilic block copolymers; however, relatively few studies have been conducted using small-angle neutron scattering techniques to discover the mechanism by which they act. SANS results reported here show that a relatively simple core-shell cylinder model can be used to fit data success...

The purpose of this research was to develop a topical microsphere delivery system in a thermosensitive 20% poloxamer 407 gel (Pluronic F127) to control release of KSL-W, a cationic antimicrobial decapeptide, for a period of 4-7 days for potential application in combat related injuries. KSL-W loaded microsphere formulations were prepared by a solvent extraction-evaporation method (water-oil-wate...

Abstract Nickel modified strontium hydroxyapatite (Ni/Sr-HAP) supported catalysts are studied in selective methanation of CO/CO 2 . In this work, a new type nano rod-shaped hydroxyapatite-based with two different sizes and aspect ratios were prepared by sol–gel method next step, Ni precursor was wet impregnated i.e., denoted as Ni/Sr-HAP Ni/Sr-HAP(F127). The catalytic tests performed CO reactio...

Objective. Objective of the present work was to develop site-specific gastroretentive drug delivery of Troxipide using polymers Pluronic F127 and Polyox 205 WSR. Troxipide is a novel gastroprotective agent with antiulcer, anti-inflammatory, and mucus secreting properties with elimination half-life of 7.4 hrs. Troxipide inhibits H. pylori-derived urease. It is mainly absorbed from stomach. Metho...

Abstract Mixed micellar systems have been tried with the aim of achieving higher solubility drugs compared to single systems. Hydrophobic-hydrophilic mixed used for above purpose drug ciprofloxacin in past. In present study, a hydrophilic-hydrophilic binary system comprising pluronic copolymers F127 and L64 has studied its effect on solubilization Ciprofloxacin. The solutions two individual the...