BACKGROUND Tobacco dependence is a chronic, relapsing condition that may require extended treatment. OBJECTIVE To assess whether extended-duration transdermal nicotine therapy increases abstinence from tobacco more than standard-duration therapy in adult smokers. DESIGN Parallel randomized, placebo-controlled trial from September 2004 to February 2008. Participants and all research personne...

the present study has a cognitive approach to empathy and character engagement in cinema. in discussing how through empathy and engagement with real and fictional characters, we extend our minds and enhance our cognitive abilities, the present paper studies bahram tavakkoli’s wandering in the fog (2010), to show how andy clark and david chalmers’s idea of the extended mind as joined with murray...

Extended pancreatoduodenectomy with portal vein and inferior vena cava resection reconstruction combined sorafenib for hepatoid carcinoma of the pancreas: a strategy superextended surgery targeted therapy

BACKGROUND Hormone receptor positive breast cancer is characterized by the potential for disease recurrence many years after initial diagnosis. Endocrine therapy has been shown to reduce the risk of such recurrence, but the optimal duration of endocrine therapy remains unclear. METHODS We conducted a systematic review and meta-analysis to quantify the benefits and harms of extended adjuvant t...

AIMS We examined the cost-effectiveness of extended smoking cessation treatment in older smokers. DESIGN Participants who completed a 12-week smoking cessation program were factorial randomized to extended cognitive behavioral treatment and extended nicotine replacement therapy. SETTING A free-standing smoking cessation clinic. PARTICIPANTS A total of 402 smokers aged 50 years and older w...

subnormal responses found in patients given interriittent COT ticosteroid therapy by Malone et al. (1970). This finding, together with the satisfactory clinical response in these patients with severe disease, suggests that a therapeutic trial of depot tetracosactrin in a dose of 0-5 mg twice weekly should be considered for the control of disease requiring steroid therapy over a prolonged period...