Leucine-rich nuclear export signals (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shuttling proteins and RNAs. The export of messenger RNA in vertebrates was, however, thought to occur by a different pathway, because inhibition by injection of a synthetic Rev NES conjugate could not be demonstrated. Here we find that peptide conjugates composed o...

The elongated and polarized characteristics of neurons render targeting of receptors to the plasma membrane of distal axonal projections and dendritic branches a major sorting task. Although the majority of biosynthetic cargo synthesis, transport, and sorting are believed to occur in the soma, local membrane protein translation and sorting has been reported recently to take place in dendrites a...

Monitoring the quality of service in a multi-domain network allows providers to ensure the control of multi-domain service performance. A multi-domain service is a service that crosses multiple domains. In this paper, we propose several mechanisms for fault detection and fault localization. A fault is detected when an end-to-end contract is not respected. Faulty domains are domains that do not ...

Abstract The European arms export control system is facing a dual crisis: An ongoing crisis of effectiveness has led to legitimacy. In many ways, that permanent one, where collective efforts regulate policy field and implement agreed-upon norms rules fail succeed. To explain the different layers crisis, we draw on global governance research International Relations legalisation approaches intern...

Marine reserves affect areas outside reserve boundaries via the displacement of fishing effort and the export of production. Here we focus on how these key factors interact to influence the results seen once reserves are created. For a settlement-limited fishery, export of increased production from within reserves can offset the effects of displaced fishing effort. We develop simple mathematica...

Bidirectional transport of proteins via the Sec61p translocon across the endoplasmic reticulum (ER) membrane is a recognized component of the ER quality control machinery. Following translocation and engagement by the luminal quality control system, misfolded and unassembled proteins are exported from the ER lumen back to the cytosol for degradation by the proteasome. Additionally, other ER con...

I am frequently asked to visit offshore production platforms to sort out problems with the oil export or the produced water quality where the ultimate issue is not poor control in the export or water-handling systems but due to over-aggressive level control at the reception end of the process. One of the tools available to decouple the front and back ends of the production train is error square...