BACKGROUND Oral sucrose (75 g) ingested 40 minutes before exercise improves exercise tolerance in McArdle disease. OBJECTIVE To determine whether a lower dose of sucrose administered closer in time to exercise could have a similar beneficial effect on exercise capacity in patients with McArdle disease. DESIGN Placebo-controlled crossover. SETTING Neuromuscular Research Unit at the Departm...

OBJECTIVE To determine whether a programme of simple, moderate exercise training increases blood volume and improves orthostatic tolerance in patients with attacks of syncope or near syncope related to orthostatic stress. DESIGN An open study in 14 patients referred with unexplained attacks of syncope, who were shown to have a low tolerance to an orthostatic stress test. Measurements were mad...

Persons with type 2 diabetes (T2D) are believed to have reduced exercise tolerance; this may be partly due to impaired exercising muscle blood flow (MBF). Whether there is an impact of T2D on exercising MBF within the typical constellation of comorbidities (hypertension, dyslipidemia, obesity) and their associated medications has not been investigated. We tested the hypothesis that small muscle...

BACKGROUND Physical exercise improves glucose metabolism and insulin sensitivity. Brain-derived neurotrophic factor (BDNF) enhances insulin activity in diabetic rodents. Because physical exercise modifies BDNF production, this study aimed to investigate the effects of chronic exercise on plasma BDNF levels and the possible effects on insulin tolerance modification in healthy rats. METHODS Wis...

conclusions in the children in this study, pacemaker accelerometers failed to meet physiological demands. results basal heart rates, maximal heart rates, and exercise tolerance were significantly lower in the children with pacemakers. age, sex, and body mass index had no effect on the heart rate slope during the exercise test. there was no significant difference between epicardial and endocardi...

Six patients with atrial fibrillation who were taking digitalis were exercised before and after 30 mg. of propranolol twice daily. Though there was a lower pulse rate at rest and on exercise in all patients, three suffered deterioration of exercise tolerance. It is concluded that propranolol does not improve the exercise tolerance of patients with atrial fibrillation whose resting ventricular r...

The effects of infusion of normal saline (NS) and glucose-insulin-potassium (GIK) with either low or high G concentrations on hemodynamics and exercise tolerance were studied in patients with angina pectoris. Studies were performed at rest and during exercise, twice before and once after one of the infusions. Eleven patients (low-G GIK group) received 150 ml of GIK solution that contained 15 g ...

The effects of infusion of normal saline (NS) and glucose-insulin-potassium (GIK) with either low or high G concentrations on hemodynamics and exercise tolerance were studied in patients with angina pectoris. Studies were performed at rest and during exercise, twice before and once after one of the infusions. Eleven patients (low-G GIK group) received 150 ml of GIK solution that contained 15 g ...

Performance in fitness tests could depend on factors beyond the bioenergetic and skeletomuscular systems, such as individual differences in preference for and tolerance of different levels of exercise-induced somatosensory stimulation. Although such individual-difference variables could play a role in exercise testing and prescription, they have been understudied. The purpose of these studies w...